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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels)
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Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels)

机译：棕榈酸抗坏血酸半固体纳米结构脂质载体的理化特性和体外释放研究

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摘要

The aim of this study was to characterize the physicochemical properties and to study in vitro release of ascorbyl palmitate from semi-solid lipid nanoparticles based on nanostructured lipid carriers (NLC gels) systems with the desired viscosity for dermal delivery. NLC gels were obtained by a one-step production procedure employing a high pressure homogenization technique using different solid lipid matrices. Ascorbyl palmitate (AP) was selected as a lipophilic active ingredient due to its range of cosmetic applications. After the production, particles within the size range 170-250 nm having polydispersity index lower than 0.3 were obtained from all formulations. After the AP incorporation into the NLC gels, the zeta potential increased to values higher than |30mV|. Almost 100% encapsulation efficiency was observed. The obtained SEM and AFM data revealed non-spherical shaped nanoparticles. From DSC and X-ray diffraction studies, it was shown that the lipid recrystallized in the solid state possessing a less ordered structure as compared to the bulk material. The release study of active-loaded NLC gel formulations using Franz diffusion cells revealed that the type of lipid matrix affects both the rate and the release pattern. The viscoelastic measurements revealed a more elastic than viscous behaviour of NLC formulations indicating a typical gel-like structure.
机译：这项研究的目的是表征理化性质，并研究基于纳米结构脂质载体（NLC凝胶）系统从半固体脂质纳米颗粒中释放抗坏血酸棕榈酸酯的特性，该系统具有所需的皮肤输送粘度。通过使用不同固体脂质基质的高压均质化技术，通过一步生产程序获得NLC凝胶。由于其在化妆品中的应用范围广，抗坏血酸棕榈酸酯（AP）被选作亲脂性活性成分。制备后，从所有制剂中获得多分散性指数低于0.3的尺寸范围为170-250nm的颗粒。在AP掺入NLC凝胶后，ζ电位增加到高于| 30mV |的值。观察到几乎100％的封装效率。所得的SEM和AFM数据显示出非球形纳米颗粒。通过DSC和X射线衍射研究，表明与固体材料相比，以固态重结晶的脂质具有较少的有序结构。使用Franz扩散池的活性负载NLC凝胶制剂的释放研究表明，脂质基质的类型会影响速率和释放模式。粘弹性测量显示出比NLC制剂的粘滞行为更具弹性，表明典型的凝胶状结构。

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