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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and characteristics of chitosan microspheres in different acetylation as drug carrier system
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Preparation and characteristics of chitosan microspheres in different acetylation as drug carrier system

机译：不同乙酰化作用的壳聚糖微球的制备及性质研究

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摘要

Chitosan microspheres (CM) and reacetylated chitosan microspheres (ACM) were successfully made by the methods of oil/water emulsification and acetic anhydride. The characteristics of the microspheres as a drug carrier system were investigated. Two microsphere samples had spherical shape with the mean diameter of 80.79 μm for CM and 81.25 μm for ACM. The in vitro degradation (pH 7.4) in the presence of lysozyme showed a slow mass loss and ACM was higher degradation compared to CM. The microspheres, especially ACM, had a high drug loading capacity of Adriamycin hydrochloride (ADM) (12.4%) and had sustained release. The cytotoxicity was evaluated in vitro via MTT assay, ACM with steadily continual adhesion to cells had no fibroblast cytotoxicity. The inhibitory rates of ADM-loading CM, ACM suspension to Tca 8113 cells were significantly outperformed that of ADM solution.
机译：通过油/水乳化和乙酸酐法成功制备了壳聚糖微球（CM）和乙酰化壳聚糖微球（ACM）。研究了微球作为药物载体系统的特性。两个微球样品具有球形形状，CM的平均直径为80.79μm，ACM的平均直径为81.25μm。与溶菌酶相比，在溶菌酶存在下的体外降解（pH 7.4）显示出缓慢的质量损失，并且ACM的降解更高。微球，特别是ACM，具有较高的阿霉素盐酸盐（ADM）载药量（12.4％），并具有持续释放作用。通过MTT测定法在体外评价细胞毒性，对细胞稳定持续粘附的ACM没有成纤维细胞的细胞毒性。载有ADM的CM，ACM悬浮液对Tca 8113细胞的抑制率明显优于ADM溶液。

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