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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of drying processes and curing time of chitosan-lysine semi-IPN beads on chlorpheniramine maleate delivery
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Effect of drying processes and curing time of chitosan-lysine semi-IPN beads on chlorpheniramine maleate delivery

机译：壳聚糖-赖氨酸半IPN珠的干燥工艺和固化时间对马来酸氯苯那敏的影响

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摘要

Beads of semi-interpenetrating polymer network (semi-IPN) have been synthesized from chitosan and lysine with varying amounts of glutaraldehyde solution used as a cross-linker. The cross-linked beads are dried by different drying processes such as air-drying, oven-drying and freeze-drying. These semi-lPNs are characterized under a scanning electron microscope (SEM). Swelling studies of these beads are carried out in different pH (2.0 and 7.4) solutions. The effect of concentration of cross-linking agent and curing period on the swelling as well as on the drug release is analysed. The results indicate that the size of matrix depend on the curing time of beads, concentration of glutaraldehyde and technique of drying. The freeze-dried beads exhibit a relatively higher percentage of swelling in the range of 66-89% as compared to oven-dried beads (53-74%) and air-dried beads (39-61%). The drug loaded beads which are cured for different time intervals followed by drying are tested for in-vitro release of chlorpheniramine maleate (CPM) drug. The rate of drug release from freeze-dried beads is much faster than that from the oven-dried and air-dried beads.
机译：已经从壳聚糖和赖氨酸中合成了半互穿聚合物网络（semi-IPN）的珠，并使用了不同数量的戊二醛溶液作为交联剂。交联的珠粒通过不同的干燥方法如风干，烤箱干燥和冷冻干燥来干燥。这些半lpn在扫描电子显微镜（SEM）下表征。这些珠粒的溶胀研究是在不同的pH（2.0和7.4）溶液中进行的。分析了交联剂的浓度和固化时间对溶胀以及对药物释放的影响。结果表明，基质的大小取决于珠子的固化时间，戊二醛的浓度和干燥技术。与烤箱干燥的珠子（53-74％）和空气干燥的珠子（39-61％）相比，冻干的珠子在66-89％的范围内表现出相对更高的溶胀百分比。测试在不同时间间隔固化然后干燥的载药小珠的马来酸氯苯那敏（CPM）药物的体外释放。冻干珠粒的药物释放速率比烘箱和风干珠粒的药物释放速率快得多。

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