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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Formulation and evaluation of nasal mucoadhesive microspheres of Sumatriptan succinate
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Formulation and evaluation of nasal mucoadhesive microspheres of Sumatriptan succinate

机译：舒马曲坦琥珀酸酯鼻粘膜粘附微球的制备与评价

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摘要

The purpose of present research work was to develop mucoadhesive microspheres for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time. For the treatment of migraine, hydroxypropyl methylcellulose (HPMC) K4M and K15M based microspheres containing sumatriptan succinate (SS) were prepared by spray-drying technique. The microspheres were evaluated with respect to the yield, particle size, incorporation efficiency, swelling property, in vitro mucoadhesion, in vitro drug release, histological study and stability. Microspheres were characterized by differential scanning calorimetry, scanning electron microscopy and X-ray diffraction study. It was found that the particle size, swelling ability and incorporation efficiency of microspheres increases with increasing drug-to-polymer ratio. HPMC-based microspheres show adequate mucoadhesion and do not have any destructive effect on nasal mucosa. On the basis of these results, SS microspheres based on HPMC may be considered as a promising nasal delivery system.
机译：当前研究工作的目的是开发用于鼻腔输送的粘膜粘附性微球，目的是避免肝首过代谢，改善治疗效果并延长停留时间。为了治疗偏头痛，通过喷雾干燥技术制备了含有舒马曲坦琥珀酸酯（SS）的羟丙基甲基纤维素（HPMC）K4M和K15M基微球。评价了微球的产率，粒径，掺入效率，溶胀性质，体外粘膜粘附，体外药物释放，组织学研究和稳定性。微球通过差示扫描量热法，扫描电子显微镜和X射线衍射研究进行了表征。已经发现，微球的粒径，溶胀能力和掺入效率随药物与聚合物的比例增加而增加。基于HPMC的微球显示出足够的粘膜粘附力，并且对鼻粘膜没有任何破坏作用。基于这些结果，基于HPMC的SS微球可被认为是有前途的鼻腔输送系统。

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