...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of nephrology. >Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate
【24h】

Calibration and precision of serum creatinine and plasma cystatin C measurement: impact on the estimation of glomerular filtration rate

机译：血清肌酐和血浆半胱氨酸蛋白酶抑制剂C测定的校准和精度：对肾小球滤过率估计的影响

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serum creatinine (SCr) is the main variable for estimating glomerular filtration rate (GFR). Due to inter-assay differences, the prevalence of chronic kidney disease (CKD) varies according to the assay used, and calibration standardization is necessary. For SCr, isotope dilution mass spectrometry (IDMS) is the gold standard. Systematic differences are observed between Jaffe and enzymatic methods. Manufacturers subtract 0.30 mg/dl from Jaffe results to match enzymatic results ('compensated Jaffe method'). The analytical performance of enzymatic methods is superior to that of Jaffe methods. In the original Modification of Diet in Renal Disease (MDRD) equation, SCr was measured by a Jaffe Beckman assay, which was later recalibrated. A limitation of this equation was an underestimation of GFR in the high range. The Chronic Kidney Disease Epidemiology (CKD-EPI) consortium proposed an equation using calibrated and IDMS traceable SCr. The gain in performance was due to improving the bias whereas the precision was comparable. The CKD-EPI equation performs better at high GFR levels (GFR >60 ml/min/1.73 m(2)). Analytical limitations have led to the recommendation to give a grade (>60 ml/min/1.73 m(2)) rather than an absolute value with the MDRD equation. By using both enzymatic and calibrated methods, this cutoff-grade could be increased to 90 ml/min/1.73 m(2) (with MDRD) and 120 ml/min/1.73 m(2) (with CKD-EPI). The superiority of the CKD-EPI equation over MDRD is analytical, but the precision gain is limited. IDMS traceable enzymatic methods have been used in the development of the Lund-Malmo (in CKD populations) and Berlin Initiative Study equations (in the elderly). The analytical errors for cystatin C are grossly comparable to issues found with SCr. Standardization is available since 2011. A reference method for cystatin C is still lacking. Equations based on standardized cystatin C or cystatin C and creatinine have been proposed. The better performance of these equations (especially the combined CKD-EPI equation) has been demonstrated.
机译：血清肌酐（SCr）是估计肾小球滤过率（GFR）的主要变量。由于测定间的差异，慢性肾脏疾病（CKD）的患病率会因所使用的测定而异，因此必须进行校准标准化。对于SCr，同位素稀释质谱（IDMS）是金标准。在Jaffe和酶法之间观察到系统差异。制造商从Jaffe结果中减去0.30 mg / dl以匹配酶促结果（“补偿Jaffe方法”）。酶法的分析性能优于Jaffe法。在最初的肾脏疾病饮食调整（MDRD）公式中，SCr是通过Jaffe Beckman测定法测量的，后来对其进行了重新校准。该方程式的局限性是在高范围内低估了GFR。慢性肾脏病流行病学（CKD-EPI）联盟提出了一个使用校准的IDMS可追踪SCr方程。性能的提高是由于改善了偏差，而精度却相当。 CKD-EPI方程在高GFR水平（GFR> 60 ml / min / 1.73 m（2））下表现更好。分析的局限性导致建议使用MDRD公式给出等级（> 60 ml / min / 1.73 m（2）），而不是绝对值。通过使用酶促方法和校准方法，该临界值可以提高到90 ml / min / 1.73 m（2）（使用MDRD）和120 ml / min / 1.73 m（2）（使用CKD-EPI）。 CKD-EPI方程相对于MDRD的优越性是可分析的，但精度增益有限。 IDMS可追踪的酶促方法已用于开发Lund-Malmo（针对CKD人群）和Berlin Initiative研究方程式（针对老年人）。胱抑素C的分析误差与SCr存在的问题大致相当。自2011年起可进行标准化。半胱氨酸蛋白酶抑制剂C的参考方法仍然缺乏。已经提出了基于标准化的胱抑素C或胱抑素C和肌酐的方程。这些方程式（尤其是组合的CKD-EPI方程式）具有更好的性能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号