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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Silk coating on poly(ε-caprolactone) microspheres for the delayed release of vancomycin
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Silk coating on poly(ε-caprolactone) microspheres for the delayed release of vancomycin

机译：聚（ε-己内酯）微球上的蚕丝涂层，可延缓万古霉素的释放

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摘要

The treatment of osteomyelitis remains a challenge for orthopaedic surgeons. Controlled release of-van-comycin from biodegradable microspheres is a promising method for eliminating infection. However, the large initial burst release may make it difficult to maintain the local vancomycin concentration superior to minimum inhibitory concentration for several weeks. The aims of this study were to explore applications of the silk fibroin (SF) as an aqueous coating material for vancomycin-loaded poly(ε-caprolactone) (PCL) microspheres, and investigate the effects of silk coating on in vitro drug release. Examinations of particle size analyses, vancomycin content, Fourier transform infrared spectroscopy, differential scanning calorim-etry, scanning electron microscopy and in vitro drug release were performed. The results showed that silk coating could reduce the large initial burst release and retard the vancomycin release. Therefore, we suggest that the SF could be used as an aqueous coating material for vancomycin-loaded PCL microspheres and prolonged the drug release. SF coating on vancomycin-loaded PCL microspheres may be considered as an effective approach to prolong the drug release and improve the anti-infection effects.
机译：对于骨科医生来说，骨髓炎的治疗仍然是一个挑战。从可生物降解的微球中控释van-comycin是消除感染的一种有前途的方法。但是，大量的初始爆发释放可能使数周内难以将当地万古霉素浓度维持在高于最低抑菌浓度的水平。这项研究的目的是探索丝素蛋白（SF）作为载有万古霉素的聚（ε-己内酯）（PCL）微球的水性涂料的应用，并研究丝涂层对体外药物释放的影响。进行了粒度分析，万古霉素含量，傅立叶变换红外光谱，差示扫描量热法，扫描电子显微镜和体外药物释放的检查。结果表明，蚕丝涂层可以减少较大的初始爆发释放并延缓万古霉素的释放。因此，我们建议SF可以用作载有万古霉素的PCL微球的水性涂料，并延长药物释放。负载万古霉素的PCL微球上的SF涂层可以被认为是延长药物释放和改善抗感染效果的有效方法。

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