• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility
【24h】

Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

机译：布洛芬固体脂质纳米粒的制备和表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24 h showing negligible cell cytotoxicity up to 15 mg/mL.
机译：通过无溶剂高压均质化（HPH）制备了布洛芬（IBU）负载的固体脂质纳米颗粒（SLN）。产生的SLN由硬脂酸，三精蛋白或三棕榈精为脂质基质和各种稳定剂组成。对生产的空载和IBU负载的SLN进行8个月的粒径稳定性分析。差示扫描量热法（DSC）和X射线衍射（XRD）用于表征冻干SLN的IBU状态。发现IBU在脂质基质内为无定形和结晶形式。冻干粉根据脂质性质显示出对IBU的溶解速率增加。 SLN在Caco-2细胞中孵育24小时，显示高达15 mg / mL的细胞毒性可忽略不计。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号