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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effect of prolonged gelling time on the intrinsic properties of barium alginate microcapsules and its biocompatibility
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Effect of prolonged gelling time on the intrinsic properties of barium alginate microcapsules and its biocompatibility

机译：延长胶凝时间对藻酸钡微胶囊内在性质及其生物相容性的影响

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摘要

Pericapsular fibrotic overgrowth (PFO) may be attributed to an immune response against microcapsules themselves or to antigen shedding through microcapsule pores from encapsulated islet tissue. Modification of microcapsules aimed at reducing pore size should prevent PFO and improve graft survival. This study investigated the effect of increased gelling time (20 vs. 2 min) in barium chloride on intrinsic properties of alginate microcapsules and tested their biocompatibility in vivo. Prolonged gelling time affected neither permeability nor size of the microcapsules. However, prolonged gelling time for 20 min produced brittle microcapsules compared to 2 min during compression test. Encapsulation of human islets in both types of microcapsules affected neither islet viability nor function. The presence of PFO when transplanted into a large animal model such as baboon and its absence in small animal models such as rodents suggest that the host immune response towards alginate microcapsules is species rather than alginate specific.
机译：包膜周围纤维化过度生长（PFO）可能归因于针对微囊本身的免疫反应或归因于微囊孔从包囊的胰岛组织脱落的抗原。旨在减小孔径的微囊修饰应防止PFO并提高移植物存活率。这项研究调查了氯化钡中胶凝时间增加（20分钟对2分钟）对藻酸盐微囊内在特性的影响，并测试了它们在体内的生物相容性。延长的胶凝时间既不影响微胶囊的渗透性也不影响其大小。然而，与压缩试验期间的2分钟相比，延长的20分钟的凝胶化时间产生了脆性微胶囊。两种类型的微胶囊中人胰岛的包囊都不会影响胰岛的生存能力和功能。当将PFO移植到大型动物模型（例如狒狒）中时，PFO的存在以及在小动物模型（例如啮齿动物）中的缺失表明，宿主对藻酸盐微囊的免疫反应是物种而非藻酸盐特异性的。

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