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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Chitosan nanoparticles for ocular delivery of cyclosporine A
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Chitosan nanoparticles for ocular delivery of cyclosporine A

机译：用于眼内递送环孢菌素A的壳聚糖纳米颗粒

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摘要

In the present study, cyclosporine A (CsA) was successfully incorporated into cationic chitosan nanoparticles by spray-drying method aiming ocular application. Physicochemical characterisation of particles was performed in detail. Among the particles prepared using three types of chitosan with different molecular weights, particles containing chitosan with medium molecular weight was selected for in vivo studies. Selection was dependent on higher incorporation and encapsulation efficiencies of CsA and also better release characteristic in simulated tear fluid. Sheep were used in in vivo studies. Biological samples were collected at predetermined time intervals and were analysed by enzyme immune assay. CsA could be detected in both aqueous and vitreous humour samples for the duration of 72 h. In vivo release profiles indicated prolonged release of active agent from positively charged chitosan formulations. This may be attributed to enhanced residence time at the corneal and conjunctival surfaces.
机译：在本研究中，针对眼部应用，通过喷雾干燥法成功地将环孢霉素A（CsA）掺入阳离子型壳聚糖纳米颗粒中。详细地进行了颗粒的物理化学表征。在使用三种具有不同分子量的壳聚糖制备的颗粒中，选择了具有中等分子量的壳聚糖的颗粒用于体内研究。选择取决于较高的CsA掺入和封装效率，以及模拟泪液中更好的释放特性。绵羊用于体内研究。以预定的时间间隔收集生物样品，并通过酶免疫测定法进行分析。在房水和玻璃体液样本中都可以检测到72小时的CsA。体内释放曲线表明活性剂从带正电荷的壳聚糖制剂中的释放时间延长。这可能归因于在角膜和结膜表面的停留时间增加。

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