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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Development of a novel drug delivery system: chitosan nanoparticles entrapped in alginate microparticles
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Development of a novel drug delivery system: chitosan nanoparticles entrapped in alginate microparticles

机译：新型药物递送系统的开发：壳聚糖纳米颗粒包裹在藻酸盐微粒中

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摘要

A novel carrier using chitosan nanoparticles entrapped into alginate microparticles is proposed for protecting molecules of interest from degradation in the digestive tract. The effects of polymer concentration, sonication, stirring, pH, and processing conditions on the physical characteristics of the carrier were studied. FITC and RBITC were used to localise the polymers within particles using CLSM. Diffusion of amaranth red (AR) from nanoparticles was quantified during dissolution under gastric and intestinal conditions. Under optimal preparation conditions, the size distribution of nanoparticles loaded with AR was uniform (690 nm) with an encapsulation efficacy of 21.9%. Alginate microparticles (285 mu m) containing a homogenous distribution of nanoparticles and polymers were obtained. At gastric pH, the carrier released less than 5% of the loaded AR and, at intestinal pH, the release was rapid and complete. The drug carriers developed shows a promising use as a vehicle suitable to protect molecules of interest after oral administration.
机译：提出了使用截留在藻酸盐微粒中的壳聚糖纳米颗粒的新型载体，用于保护目标分子免于在消化道中降解。研究了聚合物浓度，超声处理，搅拌，pH和加工条件对载体物理特性的影响。 FITC和RBITC用于使用CLSM将聚合物定位在颗粒内。在胃和肠条件下溶解期间，定量了nanoparticles菜红（AR）从纳米颗粒的扩散。在最佳制备条件下，负载有AR的纳米颗粒的尺寸分布均匀（690 nm），封装效率为21.9％。获得了包含纳米颗粒和聚合物的均匀分布的藻酸盐微粒（285μm）。在胃pH下，载体释放少于负载的AR的5％，在肠pH下，释放迅速且完全。所开发的药物载体显示出有希望的用途，作为适于在口服给药后保护目标分子的媒介物。

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