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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >AAPE proliposomes for topical atopic dermatitis treatment
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AAPE proliposomes for topical atopic dermatitis treatment

机译：AAPE脂质体用于局部特应性皮炎的治疗

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Context: Anti-inflammatory effect of advanced adipose stem cell derived protein extract (AAPE) could be improved by minimising protein degradation. Objective: To develop a proliposomal formulation of AAPE for the treatment of topical atopic dermatitis. Materials and methods: Proliposomal powder was manufactured by evaporating a solution of soy phosphatidyl choline, AAPE and Poloxamer 407 in ethanol under vacuum on sorbitol powder. Characterisation of proliposomes (zeta potential, diameter, stability and flowability) as well as in vivo efficacy in a dermatitis mouse model was investigated. Results and discussion: Reconstitution of the proliposomal powder formed liposomes of 589 +/- 3.6 nm diameter with zeta potential of -51.33 +/- 0.36 mV. Protein stability was maintained up to 90 days at 25 degrees C as proliposomes. In vivo studies on atopic dermatitis mouse model showed a significant reduction in IgE levels after topical AAPE proliposome treatment. Conclusion: AAPE proliposomes maintained protein stability and showed promising results for atopic dermatitis treatment.
机译：背景：通过减少蛋白质降解，可以改善高级脂肪干细胞衍生蛋白提取物（AAPE）的抗炎作用。目的：开发一种AAPE的脂质体制剂，用于治疗局部特应性皮炎。材料和方法：通过在真空下于山梨糖醇粉末上蒸发大豆磷脂酰胆碱，AAPE和泊洛沙姆407的乙醇溶液来制备脂质体粉末。研究了前脂质体的表征（ζ电位，直径，稳定性和流动性）以及在皮炎小鼠模型中的体内功效。结果与讨论：脂质体原粉的重建形成了直径为589 +/- 3.6 nm，ζ电位为-51.33 +/- 0.36 mV的脂质体。作为前脂质体，蛋白质稳定性在25摄氏度下可维持长达90天。对特应性皮炎小鼠模型的体内研究表明，局部用APE脂质体处理后IgE水平显着降低。结论：AAPE脂质体保持蛋白质稳定性，在特应性皮炎治疗中显示出可喜的结果。

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