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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Effective parameters for formulation of gastro adhesive nanoparticles: screening by design-of-experiments approach
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Effective parameters for formulation of gastro adhesive nanoparticles: screening by design-of-experiments approach

机译：配制胃粘胶纳米颗粒的有效参数：通过实验设计方法进行筛选

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The objective of this study was selection of most influential variable for the preparation of gastro adhesive nanoparticles of acyclovir. Effect of formulation and processing variables on various response variables were studied by a Taguchi standard orthogonal array L-8 design. Independent variables studied were the amount of gelatin, amount of glutaraldehyde, amount of Pluronic F-68, acetone addition rate, pH, stirring time and stirring speed. The size of all nanoparticulate formulations prepared as per the experimental design (Taguchi screening design) varied between 165 and 1610 nm, PDI between 0.360 and 1.00, Q6 between 7.31-34.93%, T60% between 19.2-37.6 h, entrapment efficiency between 15.70 and 83.12%, loading efficiency between 39.72 and 80.49% and mucoadhesive strength between 3.959-11.02 g. Pareto ranking analyses showed that the two most important factors affecting the selected responses were amount of gelatin and amount of Pluronic F-68 (p<0.05).
机译：这项研究的目的是选择最有影响力的变量，以制备无环鸟苷的胃黏膜纳米颗粒。通过Taguchi标准正交阵列L-8设计研究了配方和加工变量对各种响应变量的影响。研究的独立变量是明胶的量，戊二醛的量，Pluronic F-68的量，丙酮的添加速率，pH，搅拌时间和搅拌速度。根据实验设计（田口筛选设计）制备的所有纳米颗粒制剂的尺寸在165和1610 nm之间变化，PDI在0.360和1.00之间变化，Q6在7.31-34.93％之间，T60％在19.2-37.6 h之间，包封效率在15.70和70％之间。 83.12％，加载效率在39.72至80.49％之间，粘膜粘附强度在3.959-11.02 g之间。 Pareto排名分析表明，影响所选反应的两个最重要因素是明胶量和Pluronic F-68量（p <0.05）。

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