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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form
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Water-soluble betamethasone-loaded poly(lactide-co-glycolide) hollow microparticles as a sustained release dosage form

机译：水溶性倍他米松负载的聚丙交酯-乙交酯共聚物空心微粒作为缓释剂型

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摘要

In this study, betamethasone disodium phosphate-loaded microparticles were fabricated for sustained release using poly(lactide-co-glycolide) (PLGA) by spray drying and emulsion solvent evaporation/extraction techniques. Encap-sulation efficiencies ranged from 59-80% using a water-in-oil-in-oil (W/O/O) double emulsion technique and more than 90% for a spray-drying method were obtained. This was a significant improvement compared to fabrication by a water-in-oil-in-water (W/O/W) double emulsion process, which had an encapsulation efficiency of less than 15%. Multiple-phase and biphasic release profiles were observed for microparticles of PLGA 50/50 and PLGA of higher lactide contents, respectively. The PLGA 50/50 hollow microparticles fabricated using the W/O/O double emulsion technique provided a sustained release of betamethasone disodium phosphate over 3 weeks.
机译：在这项研究中，使用聚（丙交酯-共-乙交酯）（PLGA）通过喷雾干燥和乳液溶剂蒸发/萃取技术制备了倍他米松磷酸二钠负载的微粒，用于缓释。使用油包水油包水（W / O / O）双乳化技术，包封效率在59-80％的范围内，对于喷雾干燥法，包封效率达到90％以上。与通过水包油包水（W / O / W）双乳液工艺制造相比，这是一个重大改进，该工艺的封装效率不到15％。分别观察到具有较高丙交酯含量的PLGA 50/50和PLGA微粒的多相和双相释放曲线。使用W / O / O双乳剂技术制造的PLGA 50/50中空微粒在3周内提供了倍他米松磷酸二钠的持续释放。

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