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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Comparison of chitosan and gelatin coated microparticles: prepared by hot-melt method
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Comparison of chitosan and gelatin coated microparticles: prepared by hot-melt method

机译：壳聚糖和明胶包被的微粒的比较：通过热熔法制备

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摘要

The aim of this study was to compare the performance of microparticles and their release properties after coating by chitosan and gelatin, respectively. All of the poly (epsilon-caprolactone) (PCL) microparticles were prepared by the hot-melt encapsulation method and indomethacin was selected as a model drug to be encapsulated. All of the coated microparticles retained their spherical shape irrespective of the type of coating material, and the particle size of coated microparticles was similar to the uncoated ones. The indomethacin encapsulation efficiency was in the range of 8.65 (+-) 0.08-8.81(+-)0.04% for uncoated microparticles and8.22 (+-)0.04%-8.68(+-)0.08% for coated microparticles. The release of indomethacin from uncoated microparticles followed a two-exponential release profile, where indomethacin was rapidly released within 4 h during the first release phase, after that approx 20% of the drug was continuously and slowly released for up to 24 h in the second phase. The similar release profile was observed from coated microparticles irrespective of the times of coating and the type of coating materials. Both the natural coating materials, chitosan and gelatin, efficiently reduced the initial burst release and the first phase of drug release, but did not alter the second phase of drug release. In other words, chitosan and gelatin could be used to protect the drug on the surface of microparticles firm immediately contacting with the release medium and both possessed the same feature in the delay of drug release.
机译：这项研究的目的是比较分别由壳聚糖和明胶包被后的微粒性能及其释放性能。所有的聚（ε-己内酯）（PCL）微粒均通过热熔包封法制备，并选择吲哚美辛作为待包封的模型药物。不论包衣材料的类型如何，所有包被的微粒都保持其球形，并且包被的微粒的粒径与未包被的微粒相似。对于未包被的微粒，消炎痛的包封效率在8.65（+/-）0.08-8.81（+/-）0.04％的范围内，对于包被的微粒为8.22（+/-）0.04％-8.68（+/-）0.08％。吲哚美辛从未包被的微粒中释放遵循两个指数的释放曲线，在第一个释放阶段，消炎痛在4小时内迅速释放，此后约20％的药物在第二次释放中持续缓慢地释放长达24小时相。无论涂覆时间和涂覆材料的类型如何，从涂覆的微粒观察到相似的释放曲线。天然的壳聚糖和明胶包衣材料均有效地减少了最初的突释释放和药物释放的第一阶段，但没有改变药物释放的第二阶段。换句话说，壳聚糖和明胶可用于保护紧紧与释放介质接触的微粒表面上的药物，并且在延迟药物释放方面都具有相同的特征。

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