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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Lymphatic uptake of lipid nanoparticles following endotracheal administration
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Lymphatic uptake of lipid nanoparticles following endotracheal administration

机译：气管内给药后脂质纳米颗粒的淋巴吸收

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A previous publication reported the uptake into the lymphatics of pulmonary administered lipid nanoparticles (LN),after aerosolization and inhalation.In the present study LN clearance from the lungs and lymphatic uptake were further evaluated after endotracheal administration.Nanoparticles prepared with gliceryl behenate were radiolabelled by association to the lipophilic tracer D,L-hexamethylpropylene amine oxime (HMPAO) coupled with 99mTc.Labelling efficiency was 97% and stability in body fluids was demonstrated in vitro.Wistar rats were treated by endotracheal administration and lymphatic uptake was determined upon organ sampling.Endotracheally delivered LN are rapidly eliminated from rat lungs and accumulation in para-aortic,axillary and inguinal lymph nodes starts almost immediately after administration.Translocation of LN across the lung mucosa and their uptake into the lymphatics demonstrate their usefulness as potential drug carriers for lung cancer therapy,as well as for immunization purposes.
机译：先前的一篇报道报道了气雾化和吸入后经肺部给药的脂质纳米颗粒（LN）进入淋巴管的摄取。在本研究中，进一步评估了经气管内给药后从肺中清除LN和淋巴的摄取。山by酸甘油酯制备的纳米颗粒通过放射性标记亲脂示踪剂D，L-六甲基丙烯胺肟（HMPAO）与99mTc缔合，贴标签效率为97％，并在体外具有体液稳定性.Wistar大鼠经气管内给药处理，并通过器官采样确定淋巴吸收。气管内递送的LN很快从大鼠肺中消除，并且在给药后几乎立即开始积聚在主动脉旁，腋窝和腹股沟淋巴结中。LN跨肺粘膜转运并被淋巴管吸收，证明其可用作潜在的肺癌药物载体治疗以及免疫的目的。

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