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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Review and current status of emulsion/dispersion technology using an internal gelation process for the design of alginate particles
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Review and current status of emulsion/dispersion technology using an internal gelation process for the design of alginate particles

机译：使用内部胶凝工艺设计藻酸盐颗粒的乳液/分散技术的现状与回顾

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摘要

Emulsification/internal gelation has been suggested as an alternative to extrusion/external gelation in the encapsulation of several compounds including sensitive biologicals such as protein drugs.Protein-loaded microparticles offer an inert environment within the matrix and encapsulation is conducted at room temperature in a media free of organic solvents.Recently,the concept of internal gelation has been applied to formulating nanoparticles as drug delivery systems.Emulsification/internal gelation technologies available for microparticles preparation,particularly that involving alginate polymer,are described as well as recent advances towards applications in nanotechnology.Those methods show great promise as a tool for the development of encapsulation processes,especially for the new field of nanotechnology using natural polymers.
机译：已建议在某些化合物的包封中使用乳化/内部凝胶化来替代挤出/外部凝胶化，其中包括敏感的生物体（例如蛋白质药物）。蛋白质负载的微粒可在基质内提供惰性环境，并且在室温下在介质中进行封装最近，内部凝胶化的概念已被用于配制纳米颗粒作为药物传递系统。描述了可用于微粒制备的乳化/内部凝胶化技术，特别是涉及藻酸盐聚合物的技术，以及在纳米技术中应用的最新进展这些方法作为开发封装工艺的工具，特别是对于使用天然聚合物的纳米技术的新领域，显示出巨大的希望。

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