Formulation and evaluation of an oral melanoma vaccine

YIN HWA LAI; MARTIN J.DSOUZA

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Formulation and evaluation of an oral melanoma vaccine

机译：口服黑色素瘤疫苗的配制和评估

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摘要

The purpose of this study was to formulate and evaluate the physicochemical properties and efficacy of an oral melanoma vaccine.Blood,feces and vaginal wash were collected weekly and analysed by ELISA.The mortality and diameter of the tumors were determined using a vernier caliper.The oral melanoma vaccine microparticles demonstrated desirable particle size,product yield,and zeta potentials.In addition,FT-IR and DSC studies revealed that there was no significant degradation in microencapsulated extra-cellular antigen (ECA).The oral vaccine group showed 25% greater survival rate compared to the control in the efficacy and challenge studies.

机译：这项研究的目的是制定和评估口服黑色素瘤疫苗的理化特性和功效。每周收集血液，粪便和阴道洗液并通过ELISA分析。使用游标卡尺确定肿瘤的死亡率和直径。口服黑色素瘤疫苗微粒显示出理想的粒径，产物收率和zeta电位。此外，FT-IR和DSC研究表明微囊化细胞外抗原（ECA）没有明显降解。口服疫苗组显示出25％的更大在功效和挑战研究中，与对照组相比，存活率更高。

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《Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres》 |2007年第3期|共18页
作者
YIN HWA LAI; MARTIN J.DSOUZA;
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正文语种 eng
中图分类药剂学;
关键词
Melanoma; oral vaccine; bovine serum albumin; microparticles; spray drying; polymers;

机译：黑色素瘤;口服疫苗;牛血清白蛋白;微粒;喷雾干燥;聚合物;

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1. Formulation and evaluation of an oral melanoma vaccine [J] . YIN HWA LAI, MARTIN J.DSOUZA Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres . 2007,第3期

机译：口服黑色素瘤疫苗的配制和评估
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3. Preparation and preclinical evaluation of a freeze-dried formulation of a novel combined multivalent whole-cell/B-subunit oral vaccine against enterotoxigenic Escherichia coli diarrhea [J] . Borde Annika, Ekman Annelie, Larsson Anette, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2016,第Null期

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4. STUDY OF SURGICAL TREATMENT OF ORAL MALIGNANT MELANOMA AND THERAPEUTIC ANTI-CANCER VACCINE AUTOLOGOUS IN DOGS. [C] . Claudia Felizzola, Suzana Souza Annual Conference of the Veterinary Cancer Society . 2009

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5. Novel formulation: Development of oral microparticulate non-viral DNA vaccine delivery system against infectious hematopoietic necrosis virus (IHNV) in rainbow trout, statistical design in matrix tablets formulation. [D] . Tantituvanont, Angkana. 2003

机译：新型配方：开发针对虹鳟鱼中的传染性造血坏死病毒（IHNV）的口服微粒非病毒DNA疫苗输送系统，采用基质片剂配方进行统计设计。
6. Formulation and Evaluation of Oral Microparticulate Ovarian Cancer Vaccines [O] . Suprita A. Tawde, Lipika Chablani, Archana Akalkotkar, -1

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7. Evaluating and optimizing oral formulations of live bacterial vaccines using a gastro-small intestine model [O] . de Barros João M.S., Costabile Adele, Charalampopoulos Dimitris, 2016

机译：使用胃小肠模型评估和优化活细菌疫苗的口服制剂
8. Field Trial of Attenuated Salmonella typhi Live Oral Vaccine Ty21a in Liquid and Enteric-Coated Formulations and Epidemiological Survey for Incidence of Diarrhea Due to Shigella Species. [R] . Levine, M. M. 1992

机译：在液体和肠溶包衣制剂中减毒伤寒沙门氏菌口服疫苗Ty21a的现场试验和对志贺氏菌引起的腹泻发病率的流行病学调查。

Formulation and evaluation of an oral melanoma vaccine

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