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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Sealing liquid-filled pectinate capsules with a shellac coating
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Sealing liquid-filled pectinate capsules with a shellac coating

机译：用虫胶涂层密封装满液体的果胶胶囊

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摘要

Liquid-filled pectinate capsules have a large potential for the controlled and site-specific delivery of liquid drugs. Earlier studies have shown that pure pectinate capsules can store drugs only for a few minutes. Here, we show that the retention time can be extended to several hours by coating the capsules with the natural resin shellac. A bilberry extract containing anthocyanins with promising therapeutic properties was used as model drug to characterize the permeability of the capsules by in vitro drug release measurements. Characterizing the structure of the double-layered capsule membranes by NMR microscopy, we optimized the capsule production by adjusting the pH-value in the coating process and the gelation time of the pectinate hydrogel layer. A comparison of the layer thicknesses with drug release measurements reveals that capsules with the thinnest shellac layers provide the best entrapment. Additional squeezing experiments show that the shellac layer makes the capsules also mechanically more stable.
机译：液体填充的果胶酸盐胶囊具有控制液体和按部位给药的巨大潜力。较早的研究表明，纯果胶胶囊只能储存药物几分钟。在这里，我们表明通过用天然树脂紫胶包衣胶囊可以将保留时间延长到几个小时。含有花色苷且具有良好治疗特性的越桔提取物被用作模型药物，以通过体外药物释放测量来表征胶囊的渗透性。通过核磁共振显微镜表征双层胶囊膜的结构，我们通过调节包衣过程中的pH值和果胶水凝胶层的胶凝时间来优化胶囊生产。将层厚度与药物释放测量结果进行比较后发现，具有最薄虫胶层的胶囊可提供最佳包封。额外的挤压实验表明，虫胶层使胶囊在机械上也更稳定。

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