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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)
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Application of Box-Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)

机译：Box-Behnken设计在非诺贝特自微乳化药物递送系统（SMEDDS）的制备和优化中的应用

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This study was designed to optimize a fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS) by using a response surface methodology. Box-Behnken design (BBD) and its desirability function were used to optimize the SMEDDS. The independent factors were the amounts of Labrafil M 1944 CS, Labrasol, and Capryol PGMC and the dependent variables were droplet size, cumulative percentage of drug released in 30 min and equilibrium solubility of fenofibrate in SMEDDS. Various response surface graphs were used to understand the effects of each factor, and the desirability function was then adjusted to optimize SMEDDS formulation. The experimental values of optimized formulation were in close agreement with predicted values. Furthermore, in vivo pharmacokinetic study of the optimized formulation showed significant increase in relative oral bioavailability compared to that of the powder suspension. In conclusion, the BBD demonstrated its effectiveness in optimizing the SMEDDS formulation and in identifying the effects of formulation variables.
机译：这项研究旨在通过使用响应面方法优化加载非诺贝特的自微乳化药物递送系统（SMEDDS）。 Box-Behnken设计（BBD）及其合意性函数用于优化SMEDDS。独立因素是Labrafil M 1944 CS，Labrasol和Capryol PGMC的量，因变量是液滴大小，30分钟内释放的药物累积百分比以及非诺贝特在SMEDDS中的平衡溶解度。使用各种响应表面图来了解每个因素的影响，然后调整需求函数以优化SMEDDS配方。优化配方的实验值与预测值非常吻合。此外，与粉末悬浮液相比，优化制剂的体内药代动力学研究显示相对口服生物利用度显着提高。总之，BBD证明了其在优化SMEDDS配方和确定配方变量影响方面的有效性。

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