...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Synthesis, characterisation and drug release properties of microspheres of polystyrene with aliphatic polyester side-chains
【24h】

Synthesis, characterisation and drug release properties of microspheres of polystyrene with aliphatic polyester side-chains

机译：脂肪族聚酯侧链聚苯乙烯微球的合成，表征及释药性能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A series of graft copolymers consisting of polystyrene backbone with biocompatible side chains based on (co) polymers of L-lactic acid and glycolic acid were synthesised by combination two controlled polymerisations, namely, nitroxide mediated radical polymerisation (NMRP) and ring opening polymerisation (ROP) with "Click'' chemistry. The main goal of this work was to design new biodegradable microspheres using obtained graft copolymers for long-term sustained release of imatinib mesylate (IMM) as a model drug. The IMM loaded microspheres of the graft copolymers, polystyrene-g-poly(lactide-co-glycolide) (PS-g-PLLGA), polystyrene-g-poly(lactic acid) (PS-g-PLLA) and poly(lactic-coglycolicacid) (PLLGA) were then prepared by a modified water-in-oil-in-water (w(1)/o/w(2)) double emulsion/solvent evaporation technique. The optimised microspheres were characterised by particle size, encapsulation efficiency, and surface morphology also; their degradation and release properties were studied in vitro. The degradation studies of three different types of microspheres showed that the PS backbone of the graft copolymers slows down the degradation rate compared to PLLGA.
机译：通过结合两种受控聚合，即氮氧化物介导的自由基聚合（NMRP）和开环聚合（ROP），合成了一系列基于L-乳酸和乙醇酸（共）聚合物的具有生物相容性侧链的聚苯乙烯骨架和生物相容性侧链的接枝共聚物。 ），采用“点击”化学法。这项工作的主要目的是使用获得的接枝共聚物设计新型可生物降解的微球，以将甲磺酸伊马替尼（IMM）长期持续释放为模型药物。然后通过以下方法制备聚苯乙烯-g-聚（丙交酯-共-乙交酯）（PS-g-PLLGA），聚苯乙烯-g-聚（乳酸）（PS-g-PLLA）和聚（乳酸-共乙醇酸）（PLLGA）一种改进的水包水包水（w（1）/ o / w（2））双乳剂/溶剂蒸发技术，以粒径，包封效率和表面形态为特征，对优化的微球进行了表征;它们的降解和释放特性进行了研究体外。三种不同类型微球的降解研究表明，与PLLGA相比，接枝共聚物的PS主链减慢了降解速率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号