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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Structural optimization of calcium carbonate cores as templates for protein encapsulation
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Structural optimization of calcium carbonate cores as templates for protein encapsulation

机译：碳酸钙核作为蛋白质封装模板的结构优化

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摘要

The calcium carbonate (CaCO3) cores being templates for model proteins encapsulation were obtained for developing oral drug delivery systems. The influence of the characteristics of the core formation (the time, the temperature, the stirring intensity, the ultrasound treatment and drying conditions) on the size and morphology of the carbonate cores was studied. The core size was shown to decrease with increasing the stirring time and stirring intensity. Statistical analysis of the scanning electron microscopy images of the carbonate cores allowed finding a correlation between their mean diameter and the parameters of the core formation. The regularities of proteins loading into porous CaCO3 cores were determined, and different loading methods were compared quantitatively. The co-precipitation method gives cores with the proteins load about five times as much as the adsorption method. The influence of protein properties and the ionic environment of protein molecules on the loading parameters were shown.
机译：获得碳酸钙（CaCO3）核作为模型蛋白质封装的模板，用于开发口服药物递送系统。研究了岩心形成特征（时间，温度，搅拌强度，超声处理和干燥条件）对碳酸盐岩心尺寸和形貌的影响。随着搅拌时间和搅拌强度的增加，核尺寸减小。对碳酸盐岩心的扫描电子显微镜图像进行统计分析，可以发现碳酸盐岩心的平均直径与岩心形成参数之间的相关性。确定了蛋白质加载到多孔CaCO3核中的规律，并定量比较了不同的加载方法。共沉淀法使蛋白质负载的核心大约是吸附法的五倍。显示了蛋白质性质和蛋白质分子的离子环境对上样参数的影响。

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