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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Ethosomes-based topical delivery system of antihistaminic drug for treatment of skin allergies
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Ethosomes-based topical delivery system of antihistaminic drug for treatment of skin allergies

机译：基于埃索体的抗组胺药局部给药系统，用于治疗皮肤过敏

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摘要

Cetirizine is indicated for the treatment of allergic conditions such as insect bites and stings, atopic and contact dermatitis, eczema, urticaria. This investigation deals with development of a novel ethosome-based topical formulation of cetirizine dihydrochloride for effective delivery. The optimised formulation consisting of drug, phospholipon 90 G(TM) and ethanol was characterised for drug content, entrapment efficiency, pH, vesicular size, spreadability and rheological behaviour. The ex vivo permeation studies through mice skin showed highest permeation flux (16.300 +/- 0.300 mu g/h/cm(2)) and skin retention (20.686 +/- 0.517 mu g/cm(2)) for cetirizine-loaded ethosomal vesicles as compared to conventional formulations. The in vivo pharmacodynamic evaluation of optimised formulation was assessed against oxazolone-induced atopic dermatitis (AD) in mice. The parameters evaluated were reduction in scratching score, erythema score, skin hyperplasia and dermal eosinophil count. Our results suggest that ethosomes are effective carriers for dermal delivery of antihistaminic drug, cetirizine, for the treatment of AD.
机译：西替利嗪适用于治疗过敏性疾病，例如昆虫叮咬，特应性和接触性皮炎，湿疹，荨麻疹。这项研究涉及开发一种新型的基于乙醇的局部用西替利嗪盐酸盐，可有效递送。由药物，磷脂90 G（TM）和乙醇组成的优化配方具有药物含量，包封率，pH，囊泡大小，铺展性和流变性的特性。通过小鼠皮肤进行的离体渗透研究显示，西替利嗪负载的乙醛体的渗透通量最高（16.300 +/- 0.300μg / h / cm（2））和皮肤滞留性（20.686 +/- 0.517μg / cm（2））与常规制剂相比的囊泡。针对小鼠中的恶唑酮诱导的特应性皮炎（AD）评估了优化配方的体内药效学评价。评估的参数是划痕得分，红斑得分，皮肤增生和皮肤嗜酸性粒细胞计数降低。我们的结果表明，脂质体是用于抗组胺药物西替利嗪经皮递送的有效载体，用于治疗AD。

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