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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation of monodisperse aqueous microspheres containing high concentration of L-ascorbic acid by microchannel emulsification
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Preparation of monodisperse aqueous microspheres containing high concentration of L-ascorbic acid by microchannel emulsification

机译：微通道乳化法制备高浓度L-抗坏血酸单分散水微球

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摘要

Monodisperse aqueous microspheres containing high concentrations of L-ascorbic acid with different concentrations of sodium alginate (Na-ALG) and magnesium sulfate (MgSO4) were prepared by using microchannel emulsification (MCE). The continuous phase was water-saturated decane containing a 5% (w/w) hydrophobic emulsifier. The flow rate of the continuous phase was maintained at 10 mL h(-1), whereas the pressure applied to the disperse phase was varied between 3 and 25 kPa. The disperse phase optimized for successfully generating aqueous microspheres included 2% (w/w) Na-ALG and 1% (w/w) MgSO4. At a higher MgSO4 concentration, the generated microspheres resulted in coalescence and subsequent bursting. At a lower MgSO4 concentration, unstable and polydisperse microspheres were obtained. The aqueous microspheres generated from the MCs under optimized conditions had a mean particle diameter (d(av)) of 14-16 mu m and a coefficient of variation (CV) of less than 8% at the disperse phase pressures of 5-15 kPa.
机译：使用微通道乳化法（MCE）制备了含有高浓度的L-抗坏血酸和不同浓度的藻酸钠（Na-ALG）和硫酸镁（MgSO4）的单分散水微球。连续相是含有5％（w / w）疏水性乳化剂的水饱和癸烷。连续相的流速保持在10 mL h（-1），而施加到分散相的压力在3到25 kPa之间变化。为成功生成水性微球而优化的分散相包括2％（w / w）的Na-ALG和1％（w / w）的MgSO4。在较高的MgSO4浓度下，生成的微球导致聚结并随后破裂。在较低的MgSO4浓度下，获得了不稳定的多分散微球。在最佳条件下，由MC生成的水性微球的平均粒径（d（av））为14-16μm，在5-15 kPa的分散相压力下，变异系数（CV）小于8％ 。

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