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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: the effect of matrix type, polymeric additives and drug-matrix miscibility
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Spray congealing as a microencapsulation technique to develop modified-release ibuprofen solid lipid microparticles: the effect of matrix type, polymeric additives and drug-matrix miscibility

机译：喷雾凝结作为微囊化技术开发布洛芬固体脂质微粒的缓释：基质类型，聚合物添加剂和药物-基质混溶性的影响

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摘要

This study aimed to achieve modified-release of ibuprofen (IBU) by encapsulation within lipid-based matrix materials [cetyl alcohol (CA), stearic acid (SA) and glyceryl dibehenate (GB)] using spray congealing to produce solid lipid microparticles (SLMs). Polymeric additives, polyvinyl-2-pyrrolidone-vinyl-acetate and ethylcellulose, were employed as release-modifying agents. Spray-congealed SLMs yield, scanning electron microscopy (SEM)-based morphology, particle size, drug content and entrapment efficiency were investigated. The influence of matrix type, additive type and concentration and drug-matrix miscibility on release of IBU was elucidated. Yields (81.4-96.4%) and drug encapsulation efficiencies (88.4-100%) of SLMs were high for all formulations. SLMs were generally discrete, spherical and dense. Increasing additives concentration led to not only larger median size SLMs but also faster drug release due to increased hydrophilicity conferred by the additives. Solid solution systems (SA-IBU, GB-IBU) sustained the release of IBU better than solid dispersion system (CA-IBU). CA-and GB-based SLMs closely adhered to the Weibull model of drug release, while SA counterparts followed the Korsmeyer-Peppas model.
机译：这项研究旨在通过喷雾凝结生产基于脂质的基质材料[鲸蜡醇（CA），硬脂酸（SA）和二山be酸甘油酯（GB）]来实现布洛芬（IBU）的缓释，以产生固体脂质微粒（SLM） ）。使用聚合物添加剂聚乙烯-2-吡咯烷酮-乙酸乙烯酯和乙基纤维素作为脱模剂。研究了喷雾凝结的SLM的产率，基于扫描电子显微镜（SEM）的形态，粒径，药物含量和包封效率。阐明了基质类型，添加剂类型和浓度以及药物-基质混溶性对IBU释放的影响。对于所有制剂，SLM的收率（81.4-96.4％）和药物封装效率（88.4-100％）高。 SLM通常是离散的，球形的和密集的。添加剂浓度的增加不仅导致中位粒径的SLM增大，而且由于添加剂赋予的亲水性增加，药物释放也更快。固体溶液系统（SA-IBU，GB-IBU）比固体分散系统（CA-IBU）更能持久释放IBU。基于CA和GB的SLM严格遵循药物释放的Weibull模型，而SA的对应模型遵循Korsmeyer-Peppas模型。

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