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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Liquid phase coating to produce controlled-release alginate microspheres
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Liquid phase coating to produce controlled-release alginate microspheres

机译：液相包衣生产控释藻酸盐微球

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摘要

This study explored a liquid phase coating technique to produce polymethyl methacrylate(PMMA)-coated alginate microspheres.Alginate microspheres with a mean diameter of 85.6 mum were prepared using an emulsification method.The alginate microspheres,as cores,were then coated with different types of PMMA by a liquid phase coating technique.The release characteristics of these coated microspheres in simulated gastric(SGF)and intestinal(SIF)fluids and the influence of drug load on encapsulation efficiency were studied.The release of paracetamol,as a model hydro-philic drug,from the coated microspheres in SGF and SIF was greatly retarded.Release rates of Eudragit RS100-coated microspheres in SGF and SIF were similar as the rate-controlling polymer coat was insoluble in both media.Drug release from Eudragit S100-coated microspheres was more sustained in SGF than in SIF,due to the greater solubility of the coating polymer in media with pH greater than 7.0.The drug release rate was affected by the core:coat ratio.Drug release from the coated microspheres was best described by the Higuchi's square root model.The liquid phase coating technique developed offers an efficient method of coating small microspheres with markedly reduced drug loss and possible controlled drug release.
机译：这项研究探索了一种液相涂覆技术来生产聚甲基丙烯酸甲酯（PMMA）包覆的藻酸盐微球。使用乳化法制备平均直径为85.6微米的藻酸盐微球。然后将藻酸盐微球作为核，然后涂覆不同类型的通过液相包覆技术研究了PMMA。研究了这些包覆的微球在模拟胃（SGF）和肠（SIF）流体中的释放特性以及载药量对包封效率的影响。作为模型亲水剂的对乙酰氨基酚的释放药物从SGF和SIF的包被的微球中被大大抑制.Eudragit RS100包被的微球在SGF和SIF中的释放速率相似，因为速率控制的聚合物包衣不溶于两种介质.Eudragit S100包被的微球的药物释放是由于涂层聚合物在pH大于7.0的介质中具有更高的溶解度，因此SGF在SIF中比在SIF中具有更强的持久性。 Higuchi的平方根模型最好地描述了从包被的微球中释放的药物。开发的液相包被技术提供了一种有效的方法来包被小的微球，显着减少了药物的损失并可能控制了药物的释放。

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