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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization
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Preparation and characterization of Mitomycin-C loaded chitosan-coated alginate microspheres for chemoembolization

机译：丝裂霉素C负载壳聚糖包被的藻酸盐微球的制备和表征

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Mitomycin-C loaded and chitosan-coated alginate microspheres were prepared for use in chemoembolization studies.In this respect,first alginate microspheres were prepared by using a spraying method using an extrusion device with a small orifice and following suspension cross-linking in an oil phase.Chitosan-coating onto the alginate microspheres was achieved by polyionic complex formation between alginate and chitosan.CaCl_2 was used as a cross-linker for alginate microspheres.The obtained chitosan-coated alginate microspheres were spherical shaped and approx 100-400 mum average size.The microspheres were evaluated based on their swellability and the swelling ratio was changed between 50-280%.CaCl_2 concentration,stirring rate,chitosan molecular weight,chitosan concentra-tion and time for coating with chitosan were selected as the effective parameters on microsphere size and swelling ratio.Equilibrium swellings were achieved in approx 30 min.On the other hand,chitosan molecular weight,chitosan concentration and time for coating with chitosan were found as the most effective parameters on both drug loading ratio and release studies.Maximum drug loading ratio of 65% was achieved with high molecular weight (HMW) chitosan,highest chitosan concentration (i.e.1.0% v/v) and shortest time for coating with chitosan (i.e.1 h) values.
机译：制备了负载丝裂霉素C和壳聚糖包被的藻酸盐微球，用于化学栓塞研究。在这方面，首先使用喷雾方法，使用具有小孔的挤出装置，然后在油相中进行悬浮交联，制备第一个藻酸盐微球。通过在藻酸盐和壳聚糖之间形成聚离子复合物，将壳聚糖包被在藻酸盐微球上.CaCl_2被用作藻酸盐微球的交联剂，得到的壳聚糖包衣藻酸盐微球为球形，平均粒径约为100-400微米。根据其溶胀性对微球进行评价，溶胀率在50-280％之间变化。选择CaCl_2浓度，搅拌速率，壳聚糖分子量，壳聚糖浓度和壳聚糖包衣时间作为影响微球粒径和粒径的有效参数。溶胀率。在约30分钟内达到平衡溶胀。另一方面，壳聚糖分子量c壳聚糖的包被时间和壳聚糖浓度是研究载药率和释放率最有效的参数。高分子量（HMW）壳聚糖的最大载药率达到65％，最高的壳聚糖浓度（即1.0％v / v）和最短的壳聚糖涂层时间（即1小时）。

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