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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Microencapsulation of acetaminophen into poly(L-lactide) by three different emulsion solvent-evaporation methods
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Microencapsulation of acetaminophen into poly(L-lactide) by three different emulsion solvent-evaporation methods

机译：通过三种不同的乳液溶剂蒸发方法将对乙酰氨基酚微囊化为聚L-丙交酯

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摘要

Poly(L-lactide) (PLLA) microcapsules containing acetaminophen (APAP) were prepared by three emulsion solvent-evaporation methods including an O/W-emulsion method,an O/W-emulsion co-solvent method and a W/O/W-multiple-emulsion method.The average size and morphology of the microcapsules varied substantially among these three preparation methods.Various alcohol and alkane co-solvents were found to exert significant impact on the O/W-emulsion co-solvent method and a more lipophilic co-solvent such as heptane appeared to enhance drug encapsulation with an efficiency nearly double of the O/W-emulsion method.When a small amount of water was added as the internal aqueous phase in the W/O/W-multiple-emulsion method,the encapsulation efficiency was found nearly triple of that for the O/W-emulsion method.While having a higher encapsulation efficiency,the microcapsules prepared by the W/O/W-multiple-emulsion method had as good controlled release behaviour as those prepared by the O/W-emulsion method.The release kinetics of micro-capsules prepared by the O/W-emulsion method and the O/W-emulsion co-solvent (alcohol) method fitted the Higuchi model well in corroboration with the uniform distribution of APAP in PLLA matrix,i.e.the monolithic type microcapsules.However,the release kinetics of microcapsules prepared by the O/W-emulsion co-solvent (alkane) method and the W/O/W-multiple-emulsion method fitted the first-order model better,indicating the reservoir type microcapsules.
机译：采用O / W乳液法，O / W乳液共溶剂法和W / O / W三种乳剂蒸发法制备了含有对乙酰氨基酚（APAP）的聚L-丙交酯（PLLA）微胶囊。三种乳液制备方法中，微胶囊的平均大小和形态有很大差异，发现各种醇和烷烃共溶剂对O / W乳液共溶剂有很大影响，并且亲脂性更高诸如庚烷之类的助溶剂似乎以O / W乳化法的近两倍的效率增强了药物的包封性。在W / O / W多乳化法中加入少量水作为内部水相时，其包封效率几乎是O / W乳液法的三倍。虽然包封效率更高，但W / O / W多重乳液法制得的微胶囊的控释性能与制备的微囊一样好。通过O / W乳液法od。O / W乳液法和O / W乳液共溶剂（酒精）法制备的微胶囊的释放动力学与Higuchi模型非常吻合，证实了APAP在PLLA基质中的均匀分布，即O / W-乳液共溶剂（烷烃）法和W / O / W-W多元乳液法制备的微胶囊的释放动力学较好地拟合了一级模型，表明储层型微胶囊。

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