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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Investigation of the release of aspirin from spray-congealed micro-pellets
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Investigation of the release of aspirin from spray-congealed micro-pellets

机译：喷雾凝结的微丸中阿司匹林释放的研究

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The release behaviour of aspirin from spray-congealed hydrogenated soybean oil micro-pellets of different sizes was studied.The purpose of this study was to investigate the effect of particle size of micro-pellets on the drug release profile and mechanism.Micro-pellets produced were sieved into several fractions and their drug content and dissolution profiles in two media were determined.The dissolution mechanism was studied by fitting the data to release kinetic models.Micro-pellets with high encapsulation efficiency were successfully produced.The micro-pellets were able to sustain the release of aspirin in pH 1.2 and pH 6.8 dissolution media.As particle size of micro-pellets increased,the drug release rate decreased.The drug release mechanism was affected by the size of micro-pellets.Micro-pellets in the range of 90-250 mum tended to follow the first order or Higuchi model.However,micro-pellets in the range of 250-355 mum were found to follow zero-order release model.This result showed that drug release could be modified by controlling the size of micro-pellets and that controlled release of drug might be achieved by using larger size micro-pellets.
机译：研究了阿司匹林从不同尺寸的喷雾凝结氢化大豆油微丸中的释放行为，旨在研究微丸粒径对药物释放曲线和机理的影响。将其筛分为几部分，确定两种介质中的药物含量和溶出曲线，通过拟合数据以研究释放机理，研究溶出机理，成功制备了包封效率高的微丸。在pH 1.2和pH 6.8溶出介质中维持阿司匹林的释放。随着微丸粒径的增大，药物的释放速率降低。药物释放机理受微丸尺寸的影响。 90-250 mum趋向于遵循一阶或Higuchi模型，但是发现250-355 mum范围内的微丸遵循零阶释放模型。可以通过控制微丸的大小来改变药物的释放，并可以通过使用更大尺寸的微丸来实现对药物的控制释放。

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