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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil
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Novel hydrogel microspheres of chitosan and pluronic F-127 for controlled release of 5-fluorouracil

机译：壳聚糖和普卢尼克F-127的新型水凝胶微球可控制5-氟尿嘧啶的释放

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摘要

Hydrogel microspheres of chitosan (CS) and Pluronic F127 (PF-127) were prepared by the emulsion-crosslinking method employing glutaraldehyde (GA) as a crosslinker.5-Fluorouracil (5-FU),an anticancer drug with good water solubility,was encapsulated into hydrogel microspheres.Various formulations were prepared by varying the ratio of CS and PF-127,% drug loading and amount of GA.Microspheres were characterized by Fourier transform infrared (FTIR) spectroscopy to confirm the absence of chemical interactions between drug,polymer and the crosslinking agent.Scanning electron microscopy (SEM) was performed to study the surface morphology of the microspheres.SEM showed that microspheres have smooth shiny surfaces.Particle size,as measured by laser light scattering technique,gave an average size ranging from 110 to 382 mu m.Differential scanning calorimetry (DSC) and X-ray diffraction (X-RD) studies were performed to understand the crystalline nature of the drug after encapsulation into hydrogel microspheres.Encapsulation of the drug up to 86% achieved was measured by UV spectroscopy.Equilibrium swelling experiments were performed in distilled water.Diffusion coefficients (D) of water through microspheres were estimated by an empirical equation.In vitro release studies indicated the dependence of release rate on the extent of crosslinking,drug loading and the amount of PF-127 used to produce the microspheres;slow release was extended up to 24 h.The release data were also fitted to an empirical equation to compute the diffusional exponent (n),which indicated that the release mechanism followed the non-Fickian trend.
机译：以戊二醛（GA）为交联剂，通过乳液交联的方法制备了壳聚糖（CS）和Pluronic F127（PF-127）的水凝胶微球。5-氟尿嘧啶（5-FU）是一种水溶性好的抗癌药物。通过改变CS和PF-127的比例，％载药量和GA的量来制备各种制剂。通过傅里叶变换红外（FTIR）光谱对微球进行表征，以确认药物，聚合物之间不存在化学相互作用用扫描电子显微镜（SEM）研究了微球的表面形貌。SEM表明微球表面光滑有光泽。采用激光散射技术测得的平均粒径为110-250微米。 382微米进行了差示扫描量热法（DSC）和X射线衍射（X-RD）研究以了解药物在水凝胶中的结晶性质l微球：通过紫外光谱法测定的药物包封率达到86％;在蒸馏水中进行了平衡溶胀实验;通过经验方程估算了水在微球中的扩散系数（D）;体外释放研究表明了这种依赖性释放速率对交联程度，载药量和用于生产微球的PF-127用量的影响;缓慢释放延长至24小时。释放数据也与经验方程拟合以计算扩散指数（n ），表明释放机制遵循非菲克趋势。

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