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首页> 外文期刊>Journal of Microencapsulation: Microcapsules Liposomes Nanoparticles Microcells Microspheres >Preparation of doxorubicin-containing chitosan microspheres for transcatheter arterial chemoembolization of hepatocellular carcinoma
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Preparation of doxorubicin-containing chitosan microspheres for transcatheter arterial chemoembolization of hepatocellular carcinoma

机译：含阿霉素的壳聚糖微球用于肝癌经导管动脉化疗栓塞的制备

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A new form of doxorubicin hydrochloride (DRH)-containing chitosan microspheres (CMs) was prepared by employing an expanding-loading-shrinking (E-L-S) process.One hundred mg of preformed CMs were soaked in absolute ethanol and then placed in reduced pressure (the expanding process).Ten mg of DRH (2 mg ml~(-1)) were added into the expanded CMs (the loading process).Next the microspheres were freeze-dried (the shrinking process).As a result of this E-L-S process,10% (w/w) DRH-containing CMs (DRH-CM) were made.During 7 days,22.6% of the DRH was observed to be released on the in vitro drug release study.In addition,these new DRH-CMs could be used for transcatheter arterial chemoembolization (TACE) procedure in VX2 hepatic tumour models of rabbit and the anti-tumour effects of DRH-CMs were investigated.On the post-CT scan 7 days after the TACE,total infarctions of the VX2 tumour were observed in 5 rabbits among the 6 total rabbits.
机译：通过膨胀-负载-收缩（ELS）工艺制备了一种新形式的含有盐酸阿霉素的壳聚糖微球（CMs），将100 mg预制的CMs浸入无水乙醇中，然后减压放置（将十毫克DRH（2 mg ml〜（-1））加入到膨胀的CM中（加载过程），然后将微球冷冻干燥（收缩过程）。制备了10％（w / w）的含DRH的CM（DRH-CM）。在7天的时间里，体外药物释放研究观察到了22.6％的DRH被释放。此外，这些新的DRH-CM可用于家兔VX2肝肿瘤模型中的经导管动脉化疗栓塞（TACE）程序，并研究DRH-CMs的抗肿瘤作用。在TACE后7天的CT后扫描中，VX2肿瘤的总梗死在总共6只兔子中的5只兔子中观察到。

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