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首页> 外文期刊>Journal of nephrology. >Cholesterol crystal embolic disease in renal allografts.
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Cholesterol crystal embolic disease in renal allografts.

机译：肾移植物中的胆固醇晶体栓塞病。

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摘要

Cholesterol embolic disease in the renal allograft is not recognized as an important cause of graft dysfunction. We describe here two renal transplant patients with cholesterol embolization in their allograft biopsies. The first, a 48-year-old patient, received a renal transplant from a 62-year-old donor with a history of hypertension and tobacco use. On account of initial non-function, a renal biopsy was taken, which showed acute tubular necrosis and cholesterol emboli. The second, a 55-year-old man, presented chronic allograft failure six years after transplantation; ultrasonography showed a solid renal mass. Nephrectomy specimens revealed renal carcinoma and a combination of chronic rejection and multiple cholesterol emboli. Cholesterol embolic disease is probably an under-reported cause of renal graft dysfunction. The source of the emboli may be either the donor or the recipient's vessels. Since the current tendency is to accept older donors and recipients with more advanced atherosclerotic disease, this condition is likely to become more frequent in the future. Particular care must be taken at the time of organ procurement and during the evaluation of organ donors, in order to reduce the risk of embolization.
机译：肾异体移植中的胆固醇栓塞性疾病未被认为是移植物功能障碍的重要原因。我们在这里描述了两名同种异体移植活检中胆固醇栓塞的肾移植患者。第一例是48岁的患者，接受了62岁的有高血压和吸烟史的供体的肾脏移植。由于最初无功能，因此进行了肾脏活检，结果显示急性肾小管坏死和胆固醇栓塞。第二名是55岁的男性，移植后六年出现慢性同种异体移植失败。超声检查显示肾脏实性肿块。肾切除标本显示肾癌以及慢性排斥反应和多种胆固醇栓塞的组合。胆固醇栓塞病可能是肾移植功能障碍的报道不足的原因。栓子的来源可以是供体或受体的血管。由于当前的趋势是接受年龄更大的供者和患有更严重的动脉粥样硬化疾病的接受者，因此这种情况将来可能会变得更加频繁。在器官采购时和器官捐赠者评估期间，必须特别注意，以减少栓塞的风险。

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