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首页> 外文期刊>Journal of nephrology. >Protective effect of interferon-alpha on carbon tetrachloride-induced nephrotoxicity.
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Protective effect of interferon-alpha on carbon tetrachloride-induced nephrotoxicity.

机译：干扰素-α对四氯化碳诱导的肾毒性的保护作用。

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BACKGROUND: The aim of this study was to investigate the effect of chronic administration of interferon-alpha 2b for the prevention of carbon tetrachloride (CCl4)-induced oxidative stress and nephrotoxicity. METHODS: Thirty rats were divided into three groups: control, CCl4+placebo (CCl4+P) and CCl4+interferon-alpha 2b (CCl4+INF). Control rats were treated with pure olive oil. The other rats were treated for seven weeks with subcutaneous injections of CCl4 (0.15 mL /kg) in pure olive oil three times a week. Rats were killed at the end of the seventh week and renal histopathological examinations were done: specimens of renal tissue were obtained for investigating oxidative stress parameters, including malondialdehyde (MDA) and glutathione peroxidase (GSH-Px). RESULTS: Tubular changes, glomerular hypercellularity, and capillary obliteration were significantly less in the CCl4+INF group than with CCl4+P (p<0.05) and the interstitial fibrosis score for the CCl4+INF group was similar to the control group. However, the interstitial inflammation score was higher in the CCl4+INF group than the control group (p<0.05). No change was observed in the CCl4+P group. Renal MDA levels in the control and CCl4+INF groups were significantly lower than the CCl4+P group, while GSH-Px was significantly higher (p<0.001). There was no difference between the control and CCl4+INF groups in oxidative stress markers (p>0.05). CONCLUSIONS: Administration of interferon-alpha 2b to CCl4-treated rats prevented interstitial fibrosis, probably as a result of its antifibrogenic effect. It also reduced intrarenal oxidative stress in rats with CCl4-induced nephrotoxicity.
机译：背景：本研究的目的是研究长期施用干扰素-α2b预防四氯化碳（CCl4）诱导的氧化应激和肾毒性的作用。方法：30只大鼠分为三组：对照组，CCl4 +安慰剂（CCl4 + P）和CCl4 +干扰素-α2b（CCl4 + INF）。对照大鼠用纯橄榄油治疗。另一只大鼠每周三次皮下注射纯橄榄油中的CCl4（0.15 mL / kg）治疗七周。在第7周结束时处死大鼠，并进行肾脏组织病理学检查：获取肾脏组织标本以研究氧化应激参数，包括丙二醛（MDA）和谷胱甘肽过氧化物酶（GSH-Px）。结果：CCl4 + INF组的肾小管变化，肾小球高细胞性和毛细血管闭塞明显少于CCl4 + P组（p <0.05），CCl4 + INF组的间质纤维化评分与对照组相似。但是，CCl4 + INF组的间质炎症评分高于对照组（p <0.05）。 CCl4 + P组未观察到变化。对照组和CCl4 + INF组的肾脏MDA水平显着低于CCl4 + P组，而GSH-Px显着较高（p <0.001）。对照组和CCl4 + INF组之间在氧化应激标志物上没有差异（p> 0.05）。结论：干扰素-α2b给予CCl4处理的大鼠可预防间质纤维化，可能是由于其抗纤维化作用所致。它还可以降低CCl4诱导的肾毒性大鼠的肾脏内氧化应激。

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