Soluble Klotho levels in adult renal transplant recipients are modulated by recombinant human erythropoietin

Leone Francesca; Lofaro Danilo; Gigliotti Paolo; Perri Anna; Vizza Donatella; Toteda Giuseppina; Lupinacci Simona; Armentano Filomena; Papalia Teresa; Bonofiglio Renzo

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Soluble Klotho levels in adult renal transplant recipients are modulated by recombinant human erythropoietin

机译：重组人促红细胞生成素调节成年肾移植受者的可溶性Klotho水平

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Background Data on serum soluble Klotho levels in chronic kidney disease are contradictory and even less is known after renal transplantation. Experimental studies demonstrated that recombinant human erythropoietin (rhEPO) treatment mitigates Klotho reduction caused by renal damage. Therefore, this study aimed to determine serum Klotho levels in a cohort of kidney transplant recipients (KTR) and to evaluate whether rhEPO treatment can modulate, in vivo and in vitro, soluble Klotho.

机译：背景关于慢性肾脏疾病中血清可溶性Klotho水平的数据是相互矛盾的，甚至在肾脏移植后所知甚少。实验研究表明，重组人促红细胞生成素（rhEPO）治疗可减轻肾脏损害引起的Klotho减少。因此，本研究旨在确定一组肾移植受者（KTR）的血清Klotho水平，并评估rhEPO治疗是否可以在体内和体外调节可溶性Klotho。

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《Journal of nephrology.》 |2014年第5期|共9页
作者
Leone Francesca; Lofaro Danilo; Gigliotti Paolo; Perri Anna; Vizza Donatella; Toteda Giuseppina; Lupinacci Simona; Armentano Filomena; Papalia Teresa; Bonofiglio Renzo;
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正文语种 eng
中图分类泌尿科学（泌尿生殖系疾病）;
关键词
Cyclosporin A; Epithelial tubular cells; Erythropoietin stimulating agents; FGF23; Renal transplantation; Soluble Klotho;

机译：环孢菌素A;上皮小管细胞;促红细胞生成素刺激剂;FGF23;肾移植;可溶性Klotho;

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1. Soluble Klotho levels in adult renal transplant recipients are modulated by recombinant human erythropoietin [J] . Leone Francesca, Lofaro Danilo, Gigliotti Paolo, Journal of nephrology. . 2014,第5期

机译：重组人促红细胞生成素调节成年肾移植受者的可溶性Klotho水平
2. Parameters Influencing Blood Erythropoietin Levels of Renal Transplant Recipients During the Early Post-transplantation Period [J] . Kalantzi M., Kalliakmani P., Papachristou E., Transplantation Proceedings . 2014,第9期

机译：移植后早期影响肾移植受者血液促红细胞生成素水平的参数
3. Recombinant human erythropoietin mitigates reductions in renal klotho expression. [J] . Sugiura H, Yoshida T, Mitobe M, American Journal of Nephrology . 2010,第2期

机译：重组人促红细胞生成素减轻了肾脏klotho表达的降低。
4. Tacrolimus Levels in Adult Patients With Renal Transplant [C] . Ana Luisa Robles-Piedras and Eva Hilda Gonzalez-Lopez Western Pharmacology Society . 2009

机译：成年患者肾移植患者的喉血素水平
5. QuantitativeModeling and Optimal Control of Immunosuppressant Treatment Dynamics in Renal Transplant Recipients [D] . Murad, Neha. 2018

机译：肾移植受者免疫抑制治疗动力学的定量算法及最优控制
6. Randomised controlled trial of recombinant human growth hormonein prepubertal and pubertal renal transplant recipients [O] . H Maxwell, L Rees 1998

机译：重组人生长激素的随机对照试验在青春期前和青春期的肾移植患者中
7. Recovery from anti-recombinant-human-erythropoietin associated pure red cell aplasia in end-stage renal disease patients after renal transplantation [O] . K. Praditpornsilpa, S. Buranasot, N. Bhokaisuwan, 2005

机译：从肾移植后末期肾病患者中抗重组 - 人促红细胞生成素相关的纯红细胞Allasia回收

Soluble Klotho levels in adult renal transplant recipients are modulated by recombinant human erythropoietin

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