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首页> 外文期刊>Journal of Micromechanics and Microengineering >A three-dimensional hierarchical collagen scaffold fabricated by a combined solid freeform fabrication (SFF) and electrospinning process to enhance mesenchymal stem cell (MSC) proliferation
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A three-dimensional hierarchical collagen scaffold fabricated by a combined solid freeform fabrication (SFF) and electrospinning process to enhance mesenchymal stem cell (MSC) proliferation

机译：通过组合的固体自由形式制造（SFF）和静电纺丝工艺来增强间充质干细胞（MSC）增殖的三维分层胶原蛋白支架

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摘要

Collagen has the advantage of being very similar to macromolecular substances that can be recognized and metabolized in the biological environment. Although the natural material has superior property for this purpose, its use to fabricate reproducible and pore-structure-controlled 3D structures, which are designed to allow the entry of sufficient cells and the easy diffusion of nutrients, has been limited due to its low processability. Here, we propose a hybrid technology that combines a cryogenic plotting system with an electrospinning process. Using this technique, an easily pore-size-controllable hierarchical 3D scaffold consisting of micro-sized highly porous collagen strands and microano-sized collagen fibers was fabricated. The pore structure of the collagen scaffold was controlled by the collagen microanofibers, which were layered in the scaffold. The hierarchical scaffolds were characterized with respect to initial cell attachment and proliferation of bone marrow-derived mesenchymal stem cells within the scaffolds. The hierarchical scaffold exhibited incredibly enhanced initial cell attachment and cell compactness between pores of the plotted scaffold relative to the normally designed 3D collagen scaffold.
机译：胶原蛋白的优点是与在生物环境中可以识别和代谢的大分子物质非常相似。尽管天然材料为此目的具有优越的性能，但是由于其低可加工性，其用于制造可再现的且受孔结构控制的3D结构的设计受到限制，该3D结构旨在允许足够的细胞进入并易于分散养分。在这里，我们提出了一种混合技术，将低温绘图系统与静电纺丝工艺相结合。使用这种技术，制造了一种易于孔径控制的分层3D支架，该支架由微米级高度多孔的胶原蛋白链和微米/纳米级胶原蛋白纤维组成。胶原蛋白支架的孔结构由胶原微纤维/纳米纤维控制，所述胶原微纤维/纳米纤维层叠在支架中。关于支架的初始细胞附着和骨髓衍生的间充质干细胞增殖的特征，分级支架。相对于通常设计的3D胶原蛋白支架，分层支架表现出令人难以置信的增强的初始细胞附着和标绘支架的孔之间的细胞致密性。

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