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首页> 外文期刊>Journal of Neurophysiology >Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits.
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Posture-related oscillations in human cerebellar thalamus in essential tremor are enabled by voluntary motor circuits.

机译：人为小震丘脑在自然震颤中与姿势有关的振荡是由自愿运动回路引起的。

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The mechanism of essential tremor (ET) is unclear. Animal models of tremor and functional imaging studies in ET predict that the cerebellum and a cerebellar recipient thalamic nucleus (ventral intermediate, Vim) should exhibit oscillatory activity during rest and during tremor due to abnormal olivo-cerebellar activity. Physiologic responses of 152 single neurons were recorded during awake mapping of the ventral thalamus in seven patients with ET prior to thalamotomy. During postural tremor, spectral cross-correlation analysis demonstrated that 51% of the neurons studied exhibited a concentration of power at tremor frequency that was correlated with electromyography, i.e., tremor neurons. During rest, thalamic neurons did not exhibit tremor-frequency activity. Among the three thalamic nuclei surveyed, Vim had a significantly higher proportion of tremor neurons than did the principal somatic sensory nucleus (ventral caudal, Vc) or a pallidal recipient thalamic nucleus (ventral oral posterior, Vop). Neurons related to active movement (voluntary neurons) had significantly greater tremor-related activity than did nonvoluntary neurons. These findings are not consistent with a model of continuous olivo-cerebellar driving of the motor cortex through thalamic connections. Instead ET may be facilitated by motor circuits that enable tremor-related thalamic activity during voluntary movement. Additionally, a subgroup of tremor neurons with proprioceptive inputs were identified that may allow sensory feedback to access the central tremor network.
机译：原发性震颤（ET）的机制尚不清楚。在ET中进行震颤和功能成像研究的动物模型预测，由于异常的小脑小脑活动，小脑和小脑受体丘脑核（腹腔中间，Vim）在休息和震颤期间应表现出振荡活动。在丘脑切开术之前，对7例ET患者的腹侧丘脑进行清醒作图时记录了152个单神经元的生理反应。在姿势性震颤期间，频谱互相关分析表明，研究的51％的神经元在震颤频率下表现出与肌电图相关的力量集中，即震颤神经元。在休息期间，丘脑神经元未表现出震颤频率活动。在所调查的三个丘脑核中，Vim的震颤神经元比例显着高于主要的躯体感觉神经核（腹侧尾核，Vc）或recipient神经受体丘脑核（腹侧后位，Vop）。与主动运动有关的神经元（自愿神经元）比非自愿神经元具有更大的震颤相关活动。这些发现与丘脑连接运动皮质的连续小脑小脑驱动模型不一致。取而代之的是，电动机电路可促进ET，这些电路可在自愿运动期间实现与震颤有关的丘脑活动。另外，鉴定了具有本体感受输入的震颤神经元亚组，其可以允许感觉反馈访问中央震颤网络。

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