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首页> 外文期刊>Journal of Neurophysiology >Comparison of oculomotor neuronal activity in paralaminar and mediodorsal thalamus in the rhesus monkey.
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Comparison of oculomotor neuronal activity in paralaminar and mediodorsal thalamus in the rhesus monkey.

机译：恒河猴腹板和中嗅丘脑动眼神经元活动的比较。

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We previously reported that neurons in the mediodorsal thalamic nucleus (MD) are topographically organized and express spatial and nonspatial coding properties similar to those of the prefrontal areas with which they are connected. In the course of mapping the dorsal thalamus, we also studied neurons in a subset of thalamic nuclei (the caudal part of the ventral lateral nucleus (VLc), the oral part of the ventral posterior lateral nucleus (VPLo), the parvocellular part of the ventral anterior nucleus (VApc)) lateral to the MD and just across the internal medullary lamina. We compared these "paralaminar" neurons to MD neurons by having monkeys perform the same spatial and nonspatial cognitive tasks as those used to investigate the MD; these included two saccadic tasks-one requiring delayed and the other immediate responses-and one picture fixation task. Of the paralaminar thalamic neurons modulated by the saccadic tasks, a majority had saccade-related activity, and this was nearly always spatially tuned. Also, for about half of these neurons, the saccade-related activity occurred exclusively during the delayed-response task. No neurons with event-related activity in the saccadic tasks were preferentially modulated by specific picture stimuli, although other neurons were. All of these results were similar to what we had found for MD neurons. However, in contrast to the high proportion of presaccadic responses observed in the MD, the majority of saccade-related neurons in paralaminar thalamus exhibited mid- or postsaccadic activity, i.e., that started during or after the saccade. Our findings suggest that neurons in the paralaminar thalamus may be possible conduits of oculomotor feedback signals, especially during memory-guided saccades.
机译：我们以前曾报道过，中脊膜丘脑核（MD）中的神经元在地形上具有组织性，并表达与它们所连接的前额叶区域相似的空间和非空间编码特性。在绘制背侧丘脑的过程中，我们还研究了丘脑核子集（腹侧外侧核的尾部（VLc），腹侧后外侧核的口腔部分（VPLo），丘脑的小细胞部分）中的神经元。腹侧前核（VApc）在MD的外侧，正好穿过髓内膜。通过让猴子执行与研究MD相同的空间和非空间认知任务，我们将这些“层状”神经元与MD神经元进行了比较。这些任务包括两项任务（一项需要延迟而另一项需要立即做出响应）和一项图片固定任务。在由saccadic任务调制的层旁丘脑神经元中，大多数具有与扫视有关的活动，并且几乎总是在空间上进行调整。同样，对于这些神经元中的大约一半，与扫视相关的活动仅在延迟响应任务期间发生。尽管有其他神经元，但在特定的图片刺激下，没有优先执行在任务任务中与事件相关的神经元。所有这些结果与我们对MD神经元的发现相似。然而，与在MD中观察到的眼前反应高比例相反，副椎板丘脑中大多数与眼视有关的神经元表现出眼中或声后活动，即在眼视期间或之后开始。我们的发现表明，丘脑旁丘脑中的神经元可能是动眼反馈信号的可能管道，尤其是在记忆引导的扫视过程中。

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