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首页> 外文期刊>Journal of Neurophysiology >Morphology and physiology of the cerebellar vestibulolateral lobe pathways linked to oculomotor function in the goldfish.
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Morphology and physiology of the cerebellar vestibulolateral lobe pathways linked to oculomotor function in the goldfish.

机译：与金鱼的动眼功能相关的小脑前庭外侧叶通路的形态和生理学。

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Intracellular recording and single-cell labeling were combined to investigate the oculomotor circuitry of the goldfish cerebellar vestibulolateral lobe, consisting of the eminentia granularis (Egr) and caudal lobe. Purkinje cells exhibiting highly conserved vertebrate electrophysiological and morphological properties provide the direct output from the caudal lobe to the vestibular nuclei. Biocytin labeling of the Egr distinguished numerous hindbrain precerebellar sources that could be divided into either putative mechano- or vestibulosensitive nuclei based on cellular location and axon trajectories. Precerebellar neurons in a hindbrain nucleus, called Area II, were electrophysiologically characterized after antidromic activation from the Egr (>50% bilateral) and their morphology analyzed after intracellular biocytin labeling (n = 28). Bipolar spindle-shaped somas ranged widely in size with comparably scaled dendritic arbors exhibiting largely closed field configuration. Area II neurons (85%) projected to the ipsilateral Egr with most (93%) sending a collateral through the cerebellar commissure to the contralateral Egr; however, 15% projected to the contralateral Egr by crossing in the ventral hindbrain. Axon terminals in the vestibular nucleus were the only collaterals within the hindbrain. Every Area II neuron received a disynaptic EPSP after contralateral horizontal canal nerve stimulation and a disynaptic IPSP, preceded by a small EPSP (>50%), after ipsilateral activation. Vestibular synaptic potentials were of varying shape/amplitude, unrelated to neuron location in the nucleus, and thus likely a correlate of somadendritic size. The exceptional separation of eye position and eye velocity signals into two separate hindbrain nuclei represents an ideal model for understanding the precerebellar projection to the vestibulocerebellum.
机译：结合细胞内记录和单细胞标记来研究金鱼小脑前外侧叶的动眼运动回路，该叶由粒状隆突和尾叶组成。表现出高度保守的脊椎动物电生理和形态学特性的浦肯野细胞提供了从尾叶到前庭核的直接输出。 Egr的生物细胞素标记区分了许多后脑前脑源，这些源可根据细胞位置和轴突轨迹分为推定的机械或前庭敏感性核。在从Egr（> 50％双侧）进行抗drodromic激活后，对后脑核中的小脑前神经元（区域II）进行了电生理学表征，并在细胞内生物素标记后对其形态进行了分析（n = 28）。双极纺锤形的体形大小不等，具有相当比例的树状乔木表现出很大的封闭场构型。 II区神经元（85％）投射到同侧Egr，大部分（93％）通过小脑连合向对侧Egr发送侧支;然而，有15％的人通过腹侧后脑交叉投射到对侧的Egr。前庭核中的轴突末端是后脑内唯一的侧支。对侧水平管神经刺激后，每个II区神经元均接受突触性EPSP，同侧激活后，先产生小的EPSP（> 50％），然后进行突触性IPSP。前庭突触电位具有不同的形状/振幅，与神经元在核中的位置无关，因此可能与苏氏突触大小相关。将眼球位置和眼球速度信号出色地分离为两个独立的后脑核，是理解前脑向前庭小脑投射的理想模型。

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