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首页> 外文期刊>Journal of Neurophysiology >Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation.
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Enhancing encoding of a motor memory in the primary motor cortex by cortical stimulation.

机译：通过皮层刺激增强初级运动皮层中运动记忆的编码。

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Motor training results in encoding of motor memories, a form of use-dependent plasticity. Here we tested the hypothesis that transcranial magnetic stimulation (TMS) synchronously applied to a motor cortex engaged in a motor training task could enhance this plastic process. Healthy volunteers were studied in four sessions: training consisting of performance of directionally specific voluntary thumb movements (Train alone), training with TMS delivered during the execution of the training movement in a strictly temporal relationship to the motor cortex contralateral (Train+TMS synchronous(contra)) and ipsilateral (Train+TMS synchronous(ipsi)) to the training hand, and training with TMS delivered asynchronous to the training movement to the motor cortex contralateral to the training hand (Train+TMS asynchronous(contra)). Train alone, Train+TMS synchronous(contra), and Train+TMS asynchronous(contra) but not Train+TMS synchronous(ipsi) elicited a clear motor memory. The longevity of the encoded memory was significantly enhanced by Train+TMS synchronous(contra) when compared with Train alone and Train+TMS asynchronous(contra). Therefore use-dependent encoding of a motor memory can be enhanced by synchronous Hebbian stimulation of the motor cortex that drives the training task and reduced by stimulation of the homologous ipsilateral motor cortex, a result relevant for studies of cognitive and physical rehabilitation.
机译：运动训练导致运动记忆的编码，一种依赖于使用的可塑性。在这里，我们测试了以下假设：经颅磁刺激（TMS）同步应用于从事运动训练任务的运动皮层可以增强这种塑性过程。对健康的志愿者进行了四个阶段的研究：训练包括定向特定的自愿拇指运动的表现（仅训练），训练运动执行过程中提供的TMS训练与运动对侧皮质的时间关系严格（训练+ TMS同步（相反））和同侧（Train + TMS同步（ipsi））到训练手，并通过TMS进行与训练运动异步的运动传递到与训练手相反的运动皮层（Train + TMS异步（相反））。单独训练，Train + TMS同步（相反）和Train + TMS异步（相反）但不是Train + TMS同步（ipsi）引起清晰的运动记忆。与单独的Train和Train + TMS异步（对比）相比，Train + TMS同步（对比）显着提高了编码内存的寿命。因此，可以通过同步驱动驱动训练任务的运动皮层的Hebbian刺激来增强运动记忆的使用相关编码，并通过刺激同侧运动皮层来减少运动记忆的使用依赖编码，这与认知和身体康复研究有关。

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