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首页> 外文期刊>Journal of Neurophysiology >Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity.
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Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity.

机译：小脑插入核中谷氨酸的神经传递：参与经典条件下的眨眼和神经元活动。

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摘要

The cerebellar interposed nuclei (IN) are critical components of a neural network that controls the expression of classically conditioned eyeblinks. The IN receive 2 major inputs: the massive, gamma-aminobutyric acid (GABA)-mediated input from the Purkinje cells of the cerebellar cortex and the relatively weaker, glutamate-mediated input from collaterals of mossy and climbing fiber cerebellar afferent systems. To elucidate the role of IN glutamate neurotransmission in conditioned response (CR) expression, effects of blocking fast glutamatergic neurotransmission in the IN with gamma-d-glutamylglycine (DGG) on the expression of conditioned eyeblinks and on cerebellar nuclear neuronal activity were examined. Surprisingly, blocking fast glutamate receptors in the IN did not abolish CRs. DGG decreased CR incidence and slightly increased CR latency. In contrast, identical amounts of DGG applied to the cerebellar cortex abolished CRs. Similar to the behavioral effects, DGG had unexpectedly mild effects on IN neurons. At the population level, the baseline firing frequency of IN cells was not affected. After DGG injections, the incidence of excitatory modulation of cell activity in the interstimulus interval decreased but was not abolished. A combined block of fast glutamate and GABA(A) neurotransmission using a mixture of DGG and picrotoxin dramatically reduced CR incidence, increased the firing frequency of all cell types, and virtually abolished all modulation of neuronal activity. These results indicate that fast glutamate neurotransmission in the IN plays only an accessory role both in the expression of behavioral CRs and in the generation of associated neuronal activity in the IN.
机译：小脑插入核（IN）是控制经典条件下眨眼神经表达的神经网络的关键组件。 IN接收2个主要输入：小脑皮层Purkinje细胞的大量γ-氨基丁酸（GABA）介导的输入，以及苔藓和攀爬纤维小脑传入系统的侧支相对较弱的谷氨酸介导的输入。为了阐明IN谷氨酸神经传递在条件反应（CR）表达中的作用，研究了用γ-d-谷氨酰甘氨酸（DGG）阻断IN中快速谷氨酸能神经传递对条件眨眼表达和小脑核神经元活性的影响。令人惊讶的是，阻断IN中的快速谷氨酸受体并没有消除CR。 DGG降低了CR发生率，并稍微增加了CR潜伏期。相反，将相同量的DGG应用于小脑皮质则可消除CR。与行为影响相似，DGG对IN神经元具有出乎意料的轻微影响。在种群水平上，IN细胞的基线激发频率不受影响。注射DGG后，刺激间隔中细胞活性的兴奋性调节发生率降低，但并未消除。使用DGG和微毒素混合的快速谷氨酸和GABA（A）神经传递的组合阻滞可显着降低CR发生率，增加所有细胞类型的放电频率，并实际上消除了对神经元活性的所有调节。这些结果表明，IN中快速谷氨酸的神经传递在行为CR的表达和IN中相关神经元活性的产生中仅起辅助作用。

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