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首页> 外文期刊>Journal of Neurophysiology >Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats.
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Differential effects of estradiol on encoding properties of TMJ units in laminae I and V at the spinomedullary junction in female rats.

机译：雌二醇对雌性大鼠脊髓延髓交界处层板I和V中TMJ单位编码特性的差异作用。

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摘要

To determine whether estrogen status modulated dorsal horn neural activity relevant to temporomandibular joint (TMJ) processing single units were recorded in superficial and deep laminae at the trigeminal subnucleus caudalis/upper cervical cord (Vc/C1-2) junction of ovariectomized (OvX) female rats under barbiturate anesthesia after 17beta-estradiol (E2) treatment for 2 days. E2 dose-dependently enhanced the response to intra-TMJ stimulation by adenosine triphosphate (ATP) of neurons classified as nociceptive specific (NS), but not wide dynamic range (WDR), in superficial laminae. ATP caused similar responses among NS and WDR neurons from deep laminae in all groups. By contrast, the cutaneous receptive field areas of WDR, but not NS, units in superficial and deep laminae were enlarged in high E2-treated (HE2) compared with low E2-treated (LE2) females. Units from untreated or vehicle-treated male rats displayed responses similar to those of LE2 females. TMJ units in superficial laminae from females were more likely to receive convergent cutaneous input and respond to jaw movement than males, independent of E2 treatment. Western blot analysis revealed similar levels of P2X2 and P2X3 receptor protein in Vc/C1-2 or trigeminal ganglion samples in all groups. Immunohistochemistry revealed dense terminal labeling for P2X3 receptors in superficial laminae and moderate labeling in deep laminae at the Vc/C1-2 junction. These data indicated a significant linkage between estrogen status and the magnitude of articular input evoked by ATP from TMJ neurons in the superficial laminae at the Vc/C1-2 junction, whereas estrogenic modulation of TMJ neurons in deep laminae affected only the convergent input from overlying facial skin.
机译：为了确定是否与雌激素状态相关的颞下颌关节（TMJ）处理相关的背角神经活动被记录在卵巢切除（OvX）女性的三叉神经下尾/上颈索（Vc / C1-2）交界处的浅表层和深层中大鼠在17β-雌二醇（E2）治疗后2天接受巴比妥酸盐麻醉。 E2剂量依赖性地增强了浅层薄层中被分类为伤害感受性特异性（NS）而不是宽动态范围（WDR）的神经元对三磷酸腺苷（ATP）对TMJ内刺激的响应。 ATP在所有组的深层NS和WDR神经元之间引起相似的反应。相比之下，与低E2处理（LE2）的雌性相比，高E2处理（HE2）的WDR的皮肤感受野区域扩大，但浅层和深层的NS单元扩大。未经处理或用载体处理的雄性大鼠的单位显示出与LE2雌性相似的反应。来自雌性表层的TMJ单元比雄性更容易接受会聚的皮肤输入并响应颌骨运动，而与E2治疗无关。 Western印迹分析显示，所有组的Vc / C1-2或三叉神经节样本中的P2X2和P2X3受体蛋白水平相似。免疫组织化学显示，在Vc / C1-2交界处，浅表层中的P2X3受体具有密集的末端标记，而深层中则具有中等程度的标记。这些数据表明，雌激素状态与ATP诱发的Vc / C1-2连接处浅层椎板TMJ神经元的关节输入量之间存在显着联系，而深层椎板TMJ神经元的雌激素调节仅影响上覆层的会聚输入。面部皮肤。

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