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首页> 外文期刊>Journal of Neurophysiology >Local generation of theta-frequency EEG activity in the parasubiculum.
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Local generation of theta-frequency EEG activity in the parasubiculum.

机译：垂旁脑电图频率脑电活动的局部产生。

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摘要

The parasubiculum is a major component of the hippocampal formation that receives inputs from the CA1 region, anterior thalamus, and medial septum and that projects primarily to layer II of the entorhinal cortex. Hippocampal theta-frequency (4-12 Hz) electroencephalographic (EEG) activity has been correlated with sensorimotor integration, spatial navigation, and memory functions. The present study was aimed at determining if theta is also generated locally within the parasubiculum versus volume conducted from adjacent structures. In urethan-anesthetized rats, the phase-reversal of theta activity between superficial and deep layers of the parasubiculum was demonstrated using differential recordings from movable bipolar electrodes that eliminate the influence of volume-conducted activity. Parasubicular theta was abolished by atropine, and was in phase with theta in stratum radiatum/lacunosum-moleculare of the CA1 region. Whole cell current-clamp recordings in brain slices were then used to determine if parasubicular theta may be generated in part by membrane potential oscillations in layer II neurons. Membrane potential oscillations occurred in most layer II neurons, including four putative interneurons, when cells were held at near-threshold voltages using current injection. The frequency of oscillations increased from 3.2 to 6.1 Hz when bath temperature was raised from 22 to 32 degrees C, and oscillations persisted in the presence of blockers of fast ionotropic glutamatergic and GABAergic synaptic transmission. Oscillations are therefore likely generated by intrinsic, voltage-dependent ionic conductances. These results indicate that theta field activity is generated locally within the parasubiculum and that intrinsic membrane potential oscillations, synchronized by local inhibitory inputs, may contribute to the generation of this activity.
机译：副前突是海马结构的主要组成部分，其接收来自CA1区，前丘脑和中隔的输入，并且主要投射到内嗅皮层的II层。海马theta-频率（4-12 Hz）脑电图（EEG）活动已与感觉运动整合，空间导航和记忆功能相关。本研究的目的是确定相对于从邻近结构传导的体积，thesa是否在副韧带内局部产生。在使用尿烷麻醉的大鼠中，使用可移动的双极电极的差异记录消除了体积传导活动的影响，从而证明了伞旁表层和深层之间的theta活性相变。阿托品消除了亚旁角theta，并与CA1区的放射状层/十二指肠分子中的theta同相。然后，使用脑切片中的全细胞电流钳记录来确定是否可以通过II层神经元中的膜电位振荡来部分产生亚下角膜theta。当使用电流注入将细胞保持在接近阈值电压时，膜的大多数第二层神经元都会发生膜电位振荡。当浴温从22摄氏度升高到32摄氏度时，振荡频率从3.2赫兹增加到6.1赫兹，并且在快速离子型谷氨酸能和GABA能突触传递的阻滞剂存在下，振荡仍然持续。因此，振荡可能是由固有的，与电压相关的离子电导产生的。这些结果表明，theta场活动是在副肺内局部产生的，并且固有的膜电位振荡（由局部抑制输入同步化）可能有助于这种活动的产生。

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