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首页> 外文期刊>Journal of Neurophysiology >Ocular motor behavior in macaques with surgical exotropia.
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Ocular motor behavior in macaques with surgical exotropia.

机译：猕猴手术性外斜视的眼动行为。

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To provide an animal model of human exotropia, a free tenotomy of the medial recti was performed in two infant macaques. When the animals were old enough to record eye movements with video eye trackers, we measured their ductions, ocular alignment, comitance, smooth pursuit, fixation preference, and gaze stability. Partial recovery of adduction occurred in each monkey from spontaneous re-attachment of the medial rectus muscle to the eye. However, each animal was left with a relatively comitant, large angle exotropia. The magnitude of the exotropia was not affected by covering one eye. There was no dissociated vertical deviation or any significant "A" or "V" pattern to the horizontal misalignment. Smooth pursuit was more accurate when tracking nasally compared with temporally in both animals. Compensatory catch-up saccades in the tracking eye were always accompanied by conjugate movements in the deviated eye. Despite tenotomy of the medial recti, the velocity of adducting saccades was normal. Both monkeys alternated fixation, preferring to use the left eye for targets on the left side and the right eye for targets on the right. Each animal was capable of switching fixation while making accurate saccades. One of the monkeys developed a vertical pendular nystagmus, which was most prominent in the deviated eye. Macaques with ocular misalignment from medial rectus tenotomy exhibit features that are present in humans with alternating exotropia. These animals will be valuable for probing the cortical mechanisms that underlie visual suppression in strabismus.
机译：为了提供人类外斜视的动物模型，在两只婴儿猕猴中进行了直肠内侧的自由腱切术。当这些动物的年龄足以通过视频眼动仪记录眼动时，我们测量了它们的引诱，眼球对准，共同投入，平稳追逐，注视偏好和注视稳定性。内直肌自发重新附着到眼睛后，每只猴子都发生内收的部分恢复。但是，每只动物都具有相对的承诺，大角度的外斜视。覆盖一只眼睛不会影响外斜视的大小。没有解离的垂直偏差或水平未对准的任何明显的“ A”或“ V”模式。与两只动物的鼻部追踪相比，平稳追踪更准确。跟踪眼的补偿性追赶扫视总是伴随着偏眼的共轭运动。尽管内侧直肠切开术，但内扫的速度正常。两只猴子交替固定，更倾向于将左眼用于左侧目标，将右眼用于右侧目标。每只动物在做精确扫视时都能够切换固定方式。其中一只猴子发育出垂直的摆眼震，在偏斜眼中最突出。内侧直肌腱切开术引起的眼睛错位的猕猴表现出交替性外斜视存在于人类中的特征。这些动物对于探索斜视中视觉抑制基础的皮质机制将是有价值的。

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