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首页> 外文期刊>Journal of Neurophysiology >Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.
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Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties.

机译：投射到不同靶标的小鼠皮质V层神经元具有独特的生理特性。

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Layer V pyramidal neurons are anatomically and physiologically heterogeneous and project to multiple intracortical and subcortical targets. However, because most physiological studies of layer V pyramidal neurons have been carried out on unidentified cells, we know little about how anatomical and physiological properties relate to subcortical projection site. Here we combine neuroanatomical tract tracing with whole cell recordings in mouse somatosensory cortex to test whether neurons with the same projection target form discrete subpopulations and whether they have stereotyped physiological properties. Our findings indicate that corticothalamic and -trigeminal neurons are two largely nonoverlapping subpopulations, whereas callosal and corticostriatal neurons overlap extensively. The morphology as well as the intrinsic membrane and firing properties of corticothalamic and corticotrigeminal neurons differ from those of callosal and corticostriatal neurons. In addition, we find that each class of projection neuron exhibits a unique compliment of hyperpolarizing and depolarizing afterpotentials that further suggests that cortical neurons with different subcortical targets are distinct from one another.
机译：V层锥体神经元在解剖和生理上是异质的，并投射到多个皮层内和皮层下靶标。但是，由于大多数V层锥体神经元的生理学研究都是在不明细胞上进行的，因此我们对解剖学和生理学特性与皮层下投射部位之间的关系知之甚少。在这里，我们将神经解剖学轨迹与小鼠体感皮层中的全细胞记录相结合，以测试具有相同投影目标的神经元是否形成离散的亚群，以及它们是否具有定型的生理特性。我们的发现表明，皮层丘脑和三叉神经神经元是两个大部分不重叠的亚群，而call和皮层神经元则广泛重叠。皮层丘脑和皮原神经神经元的形态，内在膜和放电特性与al和皮层神经元的不同。此外，我们发现每一类投影神经元均表现出超极化和去极化后电位的独特互补，这进一步表明具有不同皮层下靶标的皮层神经元彼此不同。

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