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首页> 外文期刊>Journal of Neurophysiology >Activity changes in monkey superior colliculus during saccade adaptation.
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Activity changes in monkey superior colliculus during saccade adaptation.

机译：扫视过程中猴子上丘的活动发生变化。

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摘要

Saccades are eye movements that are used to foveate targets rapidly and accurately. Their amplitude must be adjusted continually, throughout life, to compensate for movement inaccuracies due to maturation, pathology, or aging. One possible locus for such saccade adaptation is the superior colliculus (SC), the relay for cortical commands to the premotor brain stem generator for saccades. However, previous stimulation and recording studies have disagreed as to whether saccade adaptation occurs up- or downstream of the SC. Therefore we have reexamined the behavior of SC burst neurons during saccade adaptation under conditions that were optimized to produce the biggest possible change in neuronal activity. We show that behavioral adaptation of saccade amplitude was associated with significant increases or decreases, in the number of spikes in the burst and/or changes in the shape of the movement field in 35 of 43 SC neurons tested. Of the 35, 29 had closed movement fields and 14 were classified indeterminate because the movement field could not be definitively diagnosed. Changes in the number of spikes occurred gradually during adaptation and resulted from correlated changes in burst lead and duration without consistent changes in peak burst rate. These data indicate that the great majority of SC neurons show a change in discharge in association with saccade amplitude adaptation. Based on these and previous results, we speculate that the site for saccade adaptation resides in the SC or that the SC is the final common pathway for adaptive changes that occur elsewhere in the saccade system.
机译：扫视运动是眼动运动，可用于快速准确地使目标偏离目标。在整个生命周期中，必须不断调整其振幅，以补偿由于成熟，病理或老化引起的运动误差。进行这种扫视运动适应的一种可能的原因是上丘（SC），即上皮运动前脑干发生器的皮层命令中继。但是，先前的刺激和记录研究对于扫视适应是发生在SC的上游还是下游并不一致。因此，我们已经重新检查了SC突触神经元在扫视适应过程中的行为，该条件经过优化以产生神经元活动的最大可能变化。我们显示，在43个被测试的SC神经元中的35个中，扫视幅度的行为适应与显着增加或减少，爆发的尖峰数和/或运动场形状的变化有关。在这35个运动场中，有29个运动场闭合，并且由于无法明确诊断运动场而将14个运动场归类为不确定。尖峰数量的变化在适应过程中逐渐发生，并且是由突发导联和持续时间的相关变化引起的，而峰值突发速率没有持续变化。这些数据表明，绝大多数SC神经元显示出与扫视幅度适应相关的放电变化。根据这些结果和先前的结果，我们推测扫视适应的站点位于SC中，或者SC是扫视系统其他地方发生的适应性变化的最终通用途径。

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