...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Neurophysiology >Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.
【24h】

Release and recycling of the readily releasable vesicle population in a synapse possessing no reserve population.

机译：在没有储备种群的突触中释放和回收易释放的囊泡种群。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We previously demonstrated that the tergotrochanteral muscle (TTM) of Drosophila is innervated by unique synapses that possess a small readily releasable/recycling vesicle population (active zone population), but not the larger reserve vesicle population observed at other neuromuscular junctions in this animal. Using light and electron microscopic techniques and intracellular recording from the G1 muscle fiber of the TTM, the release and recycling characteristics of the readily releasable/recycling population were observed without any possible contribution from a reserve population. Our results indicate 1) the total number of vesicles in synapses presynaptic to the G1 fiber correlates with the total number of quanta that can be released onto this fiber; 2) the number of quanta released by a single action potential onto the G1 fiber is about one half the number of morphologically "docked" vesicles in active zones onto the G1, and this ratio decreases in a partially depleted state; 3) the recycling rate at 1-Hz stimulation, a frequency that does not cause any depression, is 0.24 recycled vesicle/active zone/s; and 4) normal-appearing spontaneous release occurs from the active zone vesicle population and, unlike synapses that possess a reserve population, the frequency of this release is reduced after high-frequency evoked activity.
机译：我们以前证明果蝇的转子粗隆肌（TTM）受独特的突触支配，该突触具有小的易于释放/回收的囊泡种群（活动区种群），但在该动物的其他神经肌肉接头处没有观察到较大的储备囊泡种群。使用光镜和电子显微镜技术以及从TTM的G1肌纤维进行的细胞内记录，观察到易于释放/回收的种群的释放和回收特性，而保留种群没有任何可能的贡献。我们的结果表明：1）突触前与G1纤维接触的囊泡总数与可释放到该纤维上的量子总数有关。 2）由单个动作电位释放到G1纤维上的量子数量大约是G1活跃区域上形态学上“对接”的囊泡数量的一半，并且该比率在部分耗尽的状态下降低; 3）在1-Hz刺激下的循环速率为0.24个循环的囊泡/活性区/ s，该频率不引起任何凹陷。 4）从活动区囊泡种群中出现正常出现的自发释放，与具有储备种群的突触不同，在高频诱发活动后，这种释放的频率降低了。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号