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首页> 外文期刊>Journal of Neurophysiology >Distinct vascular conduction with cortical spreading depression.
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Distinct vascular conduction with cortical spreading depression.

机译：明显的血管传导伴皮质扩散抑制。

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Cortical spreading depression (CSD) is associated with significant vasodilatation and vasoconstriction, but the relationship between the cortical parenchymal and vascular phenomena remains poorly understood. We used optical intrinsic signal (OIS) imaging and electrophysiology to simultaneously examine the vascular and parenchymal changes that occur with CSD in anesthetized mice and rats. CSD was associated with a propagated multiphasic change in optical reflectance, with correlated negative DC shift in field potential. Dilatation of cortical surface arterioles propagated with a significantly greater intrinsic velocity than the parenchymal CSD wavefront measured by OIS and electrophysiology. Dilatation traveled in a circuitous pattern along individual arterioles, indicating specific vascular conduction as opposed to concentric propagation of a parenchymal signal. Arteriolar dilatation propagated into areas beyond the spread of parenchymal OIS and electrophysiological changes of CSD. Conversely, vasomotor activity could be experimentally dissociated from the parenchymal CSD wave. Frequent repetitive CSD evoked by continuous stimulation was associated with a reduced or absent arteriolar response despite preserved parenchymal OIS and electrophysiological changes. Similarly, dimethylsulfoxide at high concentrations (10%) inhibited arteriolar reactivity despite preserved parenchymal OIS and electrophysiological changes. These results suggest a mechanism, intrinsic to the vasculature, for propagation of vasodilatation associated with CSD. Distinct vascular conduction could be important for the pathogenesis of conditions that involve CSD, including migraine, stroke, and traumatic brain injury.
机译：皮质扩散抑制（CSD）与明显的血管扩张和血管收缩有关，但皮质实质和血管现象之间的关系仍然知之甚少。我们使用光固有信号（OIS）成像和电生理学来同时检查在麻醉的小鼠和大鼠中CSD引起的血管和实质变化。 CSD与光反射率的传播多相变化相关，并且与场电势的负直流偏移相关。皮质表面小动脉的扩张以明显高于通过OIS和电生理学测量的实质CSD波前的固有速度传播。扩张沿着单个小动脉呈circuit回状传播，表明特定的血管传导与实质信号的同心传播相反。小动脉扩张扩散到实质性OIS扩散和CSD的电生理变化之外的区域。相反，血管舒缩活性可以通过实验从实质CSD波中分离出来。尽管保留了实质性OIS和电生理学改变，但连续刺激引起的频繁重复CSD与小动脉反应减少或不相关。同样，尽管保留了实质性的OIS和电生理变化，但高浓度（10％）的二甲亚砜仍能抑制小动脉反应性。这些结果提示了脉管系统固有的，与CSD相关的血管舒张传播的机制。明显的血管传导对于涉及CSD的疾病（包括偏头痛，中风和脑外伤）的发病机理可能很重要。

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