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首页> 外文期刊>Journal of Neurophysiology >Discrete place fields of hippocampal formation interneurons.
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Discrete place fields of hippocampal formation interneurons.

机译:海马形成interneurons的离散场所。

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摘要

The spike discharge of hippocampal excitatory principal cells, also called "place cells," is highly location specific, but the discharge of local inhibitory interneurons is thought to display relatively low spatial specificity. Whereas in other brain regions, such as sensory neocortex, the activity of interneurons is often exquisitely stimulus selective and directly determines the responses of neighboring excitatory neurons, the activity of hippocampal interneurons typically lacks the requisite specificity needed to shape the defined structure of principal cell fields. Here we show that hippocampal formation interneurons have "on" fields (abrupt increases in activity) and "off" fields (abrupt decreases in activity) that are associated with the same location-specific informational content, spatial resolution, and dependency on context as the "place fields" of CA1 principal cells. This establishes that interneurons have well-defined place fields, thus having important implications for understanding how the hippocampus represents spatial information.
机译:海马兴奋性主要细胞(也称为“位置细胞”)的突峰放电具有高度的位置特异性,但局部抑制性中间神经元的放电被认为显示出较低的空间特异性。而在其他大脑区域(例如感觉新皮层)中,中间神经元的活性通常具有极好的刺激选择性,并直接决定邻近兴奋性神经元的反应,而海马中间神经元的活性通常缺乏塑造主要细胞场已定义结构所需的必要特异性。 。在这里,我们显示海马形成中间神经元具有与特定位置的信息内容,空间分辨率和对上下文的依赖相同的“开”场(活动突然增加)和“关”场(活动突然减少)。 CA1主单元的“位置字段”。这确定了中间神经元具有明确的位置场,因此对于理解海马体如何表示空间信息具有重要意义。

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