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首页> 外文期刊>Journal of Neurophysiology >Activation of 5-hydroxytryptamine type 3 receptor-expressing C-fiber vagal afferents inhibits retrotrapezoid nucleus chemoreceptors in rats.
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Activation of 5-hydroxytryptamine type 3 receptor-expressing C-fiber vagal afferents inhibits retrotrapezoid nucleus chemoreceptors in rats.

机译：表达5-羟基色胺3型受体的C纤维迷走神经传入的激活抑制大鼠的后梯形核化学感受器。

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摘要

Retrotrapezoid nucleus (RTN) chemoreceptors are regulated by inputs from the carotid bodies (CB) and from pulmonary mechanoreceptors. Here we tested whether RTN neurons are influenced by 5-hydroxytryptamine type 3 receptor-expressing C-fiber vagal afferents. In urethan-anesthetized rats, selective activation of vagal C-fiber afferents by phenylbiguanide (PBG) eliminated the phrenic nerve discharge (PND) and inhibited RTN neurons (n = 24). PBG had no inhibitory effect in vagotomized rats. Muscimol injection into the solitary tract nucleus, commissural part, reduced inhibition of PND and RTN by PBG (73%), blocked activation of PND and RTN by CB stimulation (cyanide) but had no effect on inhibition of PND and RTN by lung inflation. Bilateral injections of muscimol into interstitial solitary tract nucleus (NTS) reduced the inhibition of PND and RTN by PBG (53%), blocked the inhibitory effects of lung inflation but did not change the activation of PND and RTN neurons by CB stimulation. PBG and lung inflation activated postinspiratory neurons located within the rostral ventral respiratory group (rVRG) and inhibited inspiratory and expiratory neurons. Bilateral injections of muscimol into rVRG eliminated PND and partially decreased RTN neuron inhibition by PBG (32%). In conclusion, activation of cardiopulmonary C-fiber afferents inhibits the activity of RTN chemoreceptors. The pathway relays within a broad medial region of the NTS and involves the rVRG to a limited degree. The apnea triggered by activation of cardiopulmonary C-fiber afferents may be due in part to a reduction of the activity of RTN chemoreceptors.
机译：梯形后核（RTN）化学感受器受颈动脉体（CB）和肺机械感受器的输入调节。在这里，我们测试了RTN神经元是否受5-羟色胺3型受体表达C纤维迷走神经传入的影响。在以尿烷麻醉的大鼠中，苯基双胍（PBG）对迷走神经C纤维传入神经的选择性激活消除了nerve神经放电（PND）并抑制了RTN神经元（n = 24）。 PBG对迷走神经切断的大鼠没有抑制作用。向孤立道核，连合部分注射麝香酚，减少PBG对PND和RTN的抑制作用（73％），CB刺激（氰化物）阻断PND和RTN的激活，但对肺膨胀对PND和RTN的抑制作用无效。向间质孤立道核（NTS）双向注射麝香酚可减少PBG对PND和RTN的抑制作用（53％），阻断肺膨胀的抑制作用，但不会改变CB刺激对PND和RTN神经元的激活作用。 PBG和肺膨胀激活了位于鼻端腹侧呼吸组（rVRG）内的吸气后神经元，并抑制了吸气和呼气神经元。向rVRG双向注射麝香酚可消除PND，部分降低PBG对RTN神经元的抑制作用（32％）。总之，心肺C纤维传入的激活抑制了RTN化学感受器的活性。该通路在NTS的广泛内侧区域内中继，并在一定程度上涉及rVRG。由心肺C-纤维传入激活引起的呼吸暂停可能部分归因于RTN化学感受器活性的降低。

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