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首页> 外文期刊>Journal of Neurophysiology >Distinct prestimulus and poststimulus activation of VTA neurons correlates with stimulus detection
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Distinct prestimulus and poststimulus activation of VTA neurons correlates with stimulus detection

机译：VTA神经元的独特刺激前和刺激后激活与刺激检测相关

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摘要

Dopamine neurons of the ventral tegmental area (VTA) signal the occurrence of a reward-predicting conditioned stimulus (CS) with a subsecond duration increase in post-CS firing rate. Important theories about reward-prediction error and reward expectancy have been informed by the substantial number of studies that have examined post-CS phasic VTA neuron activity. On the other hand, the role of VTA neurons in anticipation of a reward-predicting CS and analysis of prestimulus spike rate rarely has been studied. We recorded from the VTA in rats during the 3-choice reaction time task, which has a fixed-duration prestimulus period and a difficult-to-detect stimulus. Use of a stimulus that was difficult to detect led to behavioral errors, which allowed us to compare VTA activity between trials with correct and incorrect stimulus-guided choices. We found a sustained increase in firing rate of both putative dopamine and GABA neurons during the pre-CS period of correct and incorrect trials. The poststimulus phasic response, however, was absent on incorrect trials, suggesting that the stimulusevoked phasic response of dopamine neurons may relate to stimulus detection. The prestimulus activation of VTA neurons may modulate cortical systems that represent internal states of stimulus expectation and provide a mechanism for dopamine neurotransmission to influence preparatory attention to an expected stimulus.
机译：腹侧被盖区（VTA）的多巴胺神经元发出信号，表示奖励预测性条件刺激（CS）的发生，且CS后放电率会增加亚秒的持续时间。有关奖励预测错误和奖励期望的重要理论已通过大量研究CS后阶段性VTA神经元活动的研究提供了信息。另一方面，很少研究VTA神经元在预测奖励性CS和预测兴奋性峰值率中的作用。我们在三选择反应时间任务期间从大鼠的VTA记录下来，该任务具有固定持续时间的预刺激期和难以检测的刺激。使用难以检测到的刺激会导致行为错误，这使我们能够比较具有正确和不正确刺激指导选择的试验之间的VTA活性。我们发现正确和不正确的试验前CS期间推定的多巴胺和GABA神经元的放电率持续增加。然而，在不正确的试验中没有刺激后的阶段性反应，这表明多巴胺神经元的刺激诱发的阶段性反应可能与刺激的检测有关。 VTA神经元的刺激前激活可调节代表刺激预期内部状态的皮质系统，并为多巴胺神经传递提供机制，以影响对预期刺激的预备注意。

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