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首页> 外文期刊>Journal of Neurophysiology >Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target
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Responsiveness to nicotine of neurons of the caudal nucleus of the solitary tract correlates with the neuronal projection target

机译：孤立道尾核神经元对尼古丁的反应性与神经元投射靶标相关

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The caudal nucleus of the solitary tract (NTS) is the key integrating center of visceral sensory-motor signaling supporting autonomic homeosta-sis. Two key projections of this nucleus are the parabrachial nucleus (PbN) and the dorsal motor nucleus of the vagus (DMV). The PbN integrates and relays viscerosensory information primarily to the forebrain, supporting behavioral, emotional, and endocrine responses to visceral events, while the DMV contains parasympathetic pregan-glionic cholinergic motoneurons that support primarily gastrointestinal reflexes. Subsets of caudal NTS neurons express presynaptic and somatodendritic nicotinic acetylcholine receptors (nAChRs). However, the anatomical identification of nicotine-responsive caudal NTS neurons has not been determined. This study used in vivo and ex vivo fluorescent tracing and slice patch-clamp electrophysiological recordings from anatomically identified caudal NTS neurons to test the hypothesis that the responsiveness of these cells to nicotine correlates with the target of their axonal projections. The results demonstrate that the majority of glutamatergic terminals that synapse on PbN-projecting caudal NTS neurons are unaffected by nicotine. Moreover, only a fraction of these cells express somatodendritic nAChRs. In contrast, the majority of DMV-projecting caudal NTS neurons exhibit robust presynaptic and somatodendritic responsiveness to nicotine. However, PbN-projecting neurons also exhibit significantly lower background frequencies of glutamatergic miniature postsynaptic currents than DMV-projecting neurons. Therefore, presynaptic unresponsiveness to nicotine may result from deficient glutamatergic innervation of PbN-projecting neurons. Nevertheless, the caudal NTS contains function-specific subsets of cells with target-specific responsiveness to nicotine. These results may support development of therapeutic strategies for selective targeting of specific autonomic pathways and impaired autonomic homeostasis.
机译：孤立道尾核（NTS）是内脏感觉运动信号支持自主平衡的关键整合中心。该核的两个关键投影是臂旁臂核（PbN）和迷走神经的背运动核（DMV）。 PbN主要将内脏感觉信息整合并传递给前脑，从而支持行为，情感和内分泌对内脏事件的反应，而DMV包含副交感神经前神经胶质胆碱能运动神经元，主要支持胃肠道反射。尾部NTS神经元亚群表达突触前和体树突状的烟碱型乙酰胆碱受体（nAChRs）。但是，尚未确定尼古丁反应性尾NTS神经元的解剖学鉴定。这项研究使用了体内和离体荧光示踪，以及从解剖学上鉴定出的尾部NTS神经元切片片夹钳电生理记录，以检验这些细胞对尼古丁的反应性与其轴突投射目标相关的假设。结果表明，在投射PbN的尾部NTS神经元上突触的大多数谷氨酸能受体不受尼古丁的影响。此外，这些细胞中只有一小部分表达体树突状nAChR。相比之下，大多数DMV投射的尾部NTS神经元对尼古丁表现出强健的突触前和树突状反应。但是，投射PbN的神经元也比投射DMV的神经元表现出更低的谷氨酸能微型突触后电流背景频率。因此，突触前对尼古丁的无反应可能是由投射PbN的神经元的谷氨酸能神经支配不足引起的。然而，尾部NTS包含具有特定功能的尼古丁反应性的特定功能细胞亚群。这些结果可能支持开发针对特定的自主神经通路和受损的自主稳态的治疗策略。

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